Literature DB >> 3040097

Prostaglandin E2 directly protects isolated rat gastric surface cell membranes against bile salts.

S Güldütuna, G Zimmer, W Kurtz, U Leuschner.   

Abstract

Rat gastric surface cell membranes were prepared and the effect of taurocholic acid assessed by ESR spectroscopy using the 16-doxylstearic acid spin label. Taurocholic acid increased the polar part of the spectra, indicating an augmented amount of spin label molecules with a polar environment. Concomitantly, mobility of the spin label molecule was augmented. The effect of taurocholic acid was completely prevented by the previous addition of prostaglandin E2. This suggests a direct protective efficiency of prostaglandin E2 on rat gastric surface cell membranes without the metabolic participation of intact cells.

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Year:  1987        PMID: 3040097     DOI: 10.1016/0005-2736(87)90298-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  4 in total

1.  Prostaglandin protects against bile salt induced increases in proton permeation of duodenal brush border membrane.

Authors:  D Zhao; B H Hirst
Journal:  Gut       Date:  1991-06       Impact factor: 23.059

2.  Topical prostaglandin E2 protects isolated gastric mucosa against acidified taurocholate-, but not ethanol- or aspirin-induced injury.

Authors:  T Ranta-Knuuttila; H Mustonen; E Kivilaakso
Journal:  Dig Dis Sci       Date:  2000-01       Impact factor: 3.199

3.  Effects of prostaglandin E2 on gastric irritant-induced apoptosis.

Authors:  Tatsuya Hoshino; Tatsunori Takano; Shinji Tsutsumi; Wataru Tomisato; Tomofusa Tsuchiya; Tohru Mizushima
Journal:  Dig Dis Sci       Date:  2002-10       Impact factor: 3.199

4.  Anti-human immunodeficiency virus (HIV) drug HOE/BAY946 increases membrane hydrophobicity of human lymphocytes and specifically suppresses HIV-protein synthesis.

Authors:  L Biesert; M Adamski; G Zimmer; H Suhartono; J Fuchs; U Unkelbach; R J Mehlhorn; K Hideg; R Milbradt; H Rübsamen-Waigmann
Journal:  Med Microbiol Immunol       Date:  1990       Impact factor: 3.402

  4 in total

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