Literature DB >> 3039984

The influence of the dT.dG mispair on the activity of the human DNA(cytosine-5)methyltransferase.

D J Baker, T A Hardy, S S Smith.   

Abstract

Synthetic oligodeoxynucleotides containing a dT.dG mispair at a centrally located d(pCG) dimer are methylated at a moderate rate by highly purified human DNA(cytosine-5)methyltransferase (E.C. 2.1.1.37). The presence of a mispaired dT in one strand induced the enzyme to preferentially methylate the opposite strand.

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Year:  1987        PMID： 3039984     DOI： 10.1016/0006-291x(87)90570-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  2 in total

1.  Improved chemistry for oligodeoxyribonucleotide synthesis substantially improves restriction enzyme cleavage of a synthetic 35mer.

Authors:  I K Farrance; J S Eadie; R Ivarie
Journal:  Nucleic Acids Res       Date:  1989-02-11       Impact factor: 16.971

2.  Human DNA (cytosine-5)methyltransferase selectively methylates duplex DNA containing mispairs.

Authors:  S S Smith; T A Hardy; D J Baker
Journal:  Nucleic Acids Res       Date:  1987-09-11       Impact factor: 16.971
  2 in total

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