Literature DB >> 3039979

Inhibition of bombesin-induced mitogenesis by pertussis toxin: dissociation from phospholipase C pathway.

I Zachary, J Millar, E Nånberg, T Higgins, E Rozengurt.   

Abstract

Prior incubation of quiescent cultures of Swiss 3T3 cells with pertussis toxin selectively inhibited the stimulation of DNA synthesis induced by peptides of the bombesin family. While pertussis toxin blocked mitogenesis at an early stage in the action of the peptide, the toxin did not impair the rapid stimulation of polyphosphoinositide breakdown, Ca2+ mobilization or activation of protein kinase C promoted by bombesin. Thus, inhibition of bombesin-induced mitogenesis by pertussis toxin can be dissociated from inactivation of the phospholipase C signalling pathway.

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Year:  1987        PMID： 3039979     DOI： 10.1016/0006-291x(87)90551-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Bombesin, neuromedin B and neuromedin C interact with a common rat pancreatic phosphoinositide-coupled receptor, but are differentially regulated by guanine nucleotides.

Authors:  M C Sekar; N Uemura; D H Coy; B I Hirschowitz; K E Dickinson
Journal:  Biochem J       Date:  1991-11-15       Impact factor: 3.857

Review 2.  Mutations of signal-transducing G proteins in human disease.

Authors:  P Schnabel; M Böhm
Journal:  J Mol Med (Berl)       Date:  1995-05       Impact factor: 4.599

3.  Selective reconstitution of gastrin-releasing peptide receptor with G alpha q.

Authors:  M R Hellmich; J F Battey; J K Northup
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-21       Impact factor: 11.205

4.  [Effect of typhoid infection on mitotic activity in the esophageal epithelium when mice are infected at different times of the day].

Authors:  Iu A Romanov; O A Irikov; S S Filippovich
Journal:  Biull Eksp Biol Med       Date:  1994-02

5.  Bombesin receptor in membranes from Swiss 3T3 cells. Binding characteristics, affinity labelling and modulation by guanine nucleotides.

Authors:  J Sinnett-Smith; W Lehmann; E Rozengurt
Journal:  Biochem J       Date:  1990-01-15       Impact factor: 3.857

6.  Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line.

Authors:  J B Trepel; J D Moyer; R Heikkila; E A Sausville
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

7.  Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins.

Authors:  J L Wang; S Kalyanaraman; M D Vivo; N Gautam
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

8.  A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.

Authors:  A M Pace; Y H Wong; H R Bourne
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

9.  Relationship of growth stimulated by lithium, estradiol, and EGF to phospholipase C activity in MCF-7 human breast cancer cells.

Authors:  J A Taylor; L H Grady; K S Engler; W V Welshons
Journal:  Breast Cancer Res Treat       Date:  1995-06       Impact factor: 4.872

10.  Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene.

Authors:  K Seuwen; I Magnaldo; B K Kobilka; M G Caron; J W Regan; R J Lefkowitz; J Pouysségur
Journal:  Cell Regul       Date:  1990-05
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