Literature DB >> 30399376

Paracrine effect of mesenchymal stem cell as a novel therapeutic strategy for diabetic nephropathy.

Hongde Li1, Pengfei Rong1, Xiaoqian Ma1, Wei Nie1, Cheng Chen1, Cejun Yang1, Juan Zhang1, Qiong Dong1, Wei Wang2.   

Abstract

Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Based on the role of mesenchymal stem cells (MSCs) in regenerative medicine, the MSC therapy has been considered a promising strategy to ameliorate the progression of DN. In this article, we review the therapeutic potential of MSCs in DN, mainly involving MSC paracrine mechanism based on trophic factors and extracellular vesicles. Knowledge of mechanism underlying the therapeutic action of MSCs on DN can provide much needed new drug targets for this disease.
Copyright © 2018. Published by Elsevier Inc.

Entities:  

Keywords:  Diabetic nephropathy; Mesenchymal stem cells; Paracrine; Regenerative medicine

Mesh：

Year:  2018        PMID： 30399376     DOI： 10.1016/j.lfs.2018.11.001

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  15 in total

1.  Mechanism of Action of Mesenchymal Stem Cells (MSCs): impact of delivery method.

Authors:  Luiza L Bagno; Alessandro G Salerno; Wayne Balkan; Joshua M Hare
Journal:  Expert Opin Biol Ther       Date:  2021-12-27       Impact factor: 4.388

Review 2.  The future of diabetic kidney disease management: what to expect from the experimental studies?

Authors:  Federica Barutta; Stefania Bellini; Beatrice Corbetta; Marilena Durazzo; Gabriella Gruden
Journal:  J Nephrol       Date:  2020-03-27       Impact factor: 3.902

Review 3.  Stem Cell Therapies in Kidney Diseases: Progress and Challenges.

Authors:  Cinzia Rota; Marina Morigi; Barbara Imberti
Journal:  Int J Mol Sci       Date:  2019-06-07       Impact factor: 5.923

4.  Mesenchymal Stem Cells Reduce Corneal Fibrosis and Inflammation via Extracellular Vesicle-Mediated Delivery of miRNA.

Authors:  Golnar Shojaati; Irona Khandaker; Martha L Funderburgh; Mary M Mann; Rohan Basu; Donna B Stolz; Moira L Geary; Aurélie Dos Santos; Sophie X Deng; James L Funderburgh
Journal:  Stem Cells Transl Med       Date:  2019-07-10       Impact factor: 6.940

5.  Mouse Umbilical Cord Mesenchymal Stem Cell Paracrine Alleviates Renal Fibrosis in Diabetic Nephropathy by Reducing Myofibroblast Transdifferentiation and Cell Proliferation and Upregulating MMPs in Mesangial Cells.

Authors:  Hongde Li; Pengfei Rong; Xiaoqian Ma; Wei Nie; Yan Chen; Juan Zhang; Qiong Dong; Min Yang; Wei Wang
Journal:  J Diabetes Res       Date:  2020-05-02       Impact factor: 4.011

6.  MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway.

Authors:  Fengyun Zhang; Fei Gao; Kun Wang; Xiaohong Liu; Zhuoqi Zhang
Journal:  Stem Cell Res Ther       Date:  2021-02-05       Impact factor: 6.832

7.  Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling.

Authors:  Ji Hye Kwon; Miyeon Kim; Soyoun Um; Hyang Ju Lee; Yun Kyung Bae; Soo Jin Choi; Hyun Ho Hwang; Wonil Oh; Hye Jin Jin
Journal:  Cells       Date:  2021-01-03       Impact factor: 6.600

8.  Resveratrol Pretreatment Improved Heart Recovery Ability of Hyperglycemic Bone Marrow Stem Cells Transplantation in Diabetic Myocardial Infarction by Down-Regulating MicroRNA-34a.

Authors:  Fengyun Zhang; Kun Wang; Fei Gao; Yongli Xuan; Xiaohong Liu; Zhuoqi Zhang
Journal:  Front Pharmacol       Date:  2021-04-20       Impact factor: 5.810

9.  Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis.

Authors:  E Xiang; Bing Han; Quan Zhang; Wei Rao; Zhangfan Wang; Cheng Chang; Yaqi Zhang; Chengshu Tu; Changyong Li; Dongcheng Wu
Journal:  Stem Cell Res Ther       Date:  2020-08-03       Impact factor: 6.832

10.  Anti-Fibrotic Effect of Human Wharton's Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1.

Authors:  Alee Choi; Sang Eon Park; Jang Bin Jeong; Suk-Joo Choi; Soo-Young Oh; Gyu Ha Ryu; Jeehun Lee; Hong Bae Jeon; Jong Wook Chang
Journal:  Int J Mol Sci       Date:  2020-08-29       Impact factor: 5.923
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