Literature DB >> 30397020

The Impact of Next-Generation Sequencing on Cancer Genomics: From Discovery to Clinic.

Elaine R Mardis1.   

Abstract

The application of next-generation sequencing (NGS) technology to the study of cancer genomes has been transformational. Not only has this technology revealed the genetic and epigenetic underpinnings of disease onset and progression, but also has redefined our clinical diagnosis and treatment paradigms. This rapid translation from discovery to clinical platform has occurred in the context of new pharmaceutical paradigms, enabling the use of NGS for the diagnosis and definition of therapeutic vulnerabilities of cancer. This review explores this transformation and identifies cutting-edge applications of NGS that will result in its additional utility in cancer care.
Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.

Entities:  

Year:  2019        PMID： 30397020     DOI： 10.1101/cshperspect.a036269

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  9 in total

1.  Extensive protein dosage compensation in aneuploid human cancers.

Authors:  Klaske M Schukken; Jason M Sheltzer
Journal:  Genome Res       Date:  2022-06-14       Impact factor: 9.438

2.  Propranolol inhibits stemness of hemangioma through Jagged1.

Authors:  Xiaorong Ma; Kaiyang Lv; Liming Wu; Tianxiang Ouyang
Journal:  Ann Transl Med       Date:  2021-11

Review 3.  Circulating tumor DNA: current challenges for clinical utility.

Authors:  Donna K Dang; Ben H Park
Journal:  J Clin Invest       Date:  2022-06-15       Impact factor: 19.456

Review 4.  A Genomic Information Management System for Maintaining Healthy Genomic States and Application of Genomic Big Data in Clinical Research.

Authors:  Jeong-An Gim
Journal:  Int J Mol Sci       Date:  2022-05-25       Impact factor: 6.208

Review 5.  Strategic vision for improving human health at The Forefront of Genomics.

Authors:  Eric D Green; Chris Gunter; Leslie G Biesecker; Valentina Di Francesco; Carla L Easter; Elise A Feingold; Adam L Felsenfeld; David J Kaufman; Elaine A Ostrander; William J Pavan; Adam M Phillippy; Anastasia L Wise; Jyoti Gupta Dayal; Britny J Kish; Allison Mandich; Christopher R Wellington; Kris A Wetterstrand; Sarah A Bates; Darryl Leja; Susan Vasquez; William A Gahl; Bettie J Graham; Daniel L Kastner; Paul Liu; Laura Lyman Rodriguez; Benjamin D Solomon; Vence L Bonham; Lawrence C Brody; Carolyn M Hutter; Teri A Manolio
Journal:  Nature       Date:  2020-10-28       Impact factor: 49.962

6.  Barrett's esophagus network analysis revealed that arginine, alanine, aspartate, glutamate, valine, leucine and isoleucine can be biomarkers.

Authors:  Mohammad Reza Zali; Mohammad-Mehdi Zadeh-Esmaeel; Majid Rezaei Tavirani; Sina Rezaei Tavirani; Mohsen Norouzinia; Mostafa Rezaei-Tavirani
Journal:  Gastroenterol Hepatol Bed Bench       Date:  2018

Review 7.  Machine Learning: A New Prospect in Multi-Omics Data Analysis of Cancer.

Authors:  Babak Arjmand; Shayesteh Kokabi Hamidpour; Akram Tayanloo-Beik; Parisa Goodarzi; Hamid Reza Aghayan; Hossein Adibi; Bagher Larijani
Journal:  Front Genet       Date:  2022-01-27       Impact factor: 4.599

Review 8.  Genetic Clonality as the Hallmark Driving Evolution of Non-Small Cell Lung Cancer.

Authors:  Marcin Nicoś; Paweł Krawczyk
Journal:  Cancers (Basel)       Date:  2022-04-02       Impact factor: 6.639

9.  A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage.

Authors:  Xueqing Zou; Gene Ching Chiek Koh; Arjun Scott Nanda; Andrea Degasperi; Katie Urgo; Theodoros I Roumeliotis; Chukwuma A Agu; Cherif Badja; Sophie Momen; Jamie Young; Tauanne Dias Amarante; Lucy Side; Glen Brice; Vanesa Perez-Alonso; Daniel Rueda; Celine Gomez; Wendy Bushell; Rebecca Harris; Jyoti S Choudhary; Josef Jiricny; William C Skarnes; Serena Nik-Zainal
Journal:  Nat Cancer       Date:  2021-04-26
  9 in total

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