Masakuni Sakaguchi1, Toshiya Maebayashi2, Takuya Aizawa2, Naoya Ishibashi2. 1. Department of Radiology, Nihon University School of Medicine, Tokyo, Japan sakaguchi.masakuni@nihon-u.ac.jp. 2. Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
Abstract
AIM: To evaluate outcomes of breast cancer patients with confirmed dural metastasis (DM) alone who received whole-brain radiation therapy (WBRT). PATIENTS AND METHODS: The medical records of thirty-three breast cancer patients who received WBRT to treat intracranial metastasis were retrospectively reviewed. The clinical presentation of DM-only was compared with that of brain metastasis (BM)/leptomeningeal metastasis (LM). RESULTS: Eight patients had DM and 25 patients had BM/LM. Median survival was 12 months in patients with DM and 7 months in those with BM/LM. Multivariate analysis found that only a Karnofsky performance status of ≥70 was significantly associated with improved OS. DM did not cause the death of any patient. Symptoms did not worsen in any DM patient. CONCLUSION: WBRT can be considered for patients with DM alone for symptom improvement and preventing DM-related death. Copyright
AIM: To evaluate outcomes of breast cancerpatients with confirmed dural metastasis (DM) alone who received whole-brain radiation therapy (WBRT). PATIENTS AND METHODS: The medical records of thirty-three breast cancerpatients who received WBRT to treat intracranial metastasis were retrospectively reviewed. The clinical presentation of DM-only was compared with that of brain metastasis (BM)/leptomeningeal metastasis (LM). RESULTS: Eight patients had DM and 25 patients had BM/LM. Median survival was 12 months in patients with DM and 7 months in those with BM/LM. Multivariate analysis found that only a Karnofsky performance status of ≥70 was significantly associated with improved OS. DM did not cause the death of any patient. Symptoms did not worsen in any DMpatient. CONCLUSION: WBRT can be considered for patients with DM alone for symptom improvement and preventing DM-related death. Copyright