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Literature DB >> 30396811

Immunocorrelates of CAF family adjuvants.

Gabriel Kristian Pedersen¹, Peter Andersen¹, Dennis Christensen².

Abstract

The development of the CAF family adjuvant was initiated around 20 years ago when Statens Serum Institut was preparing its first generation protein based recombinant subunit vaccine against tuberculosis for clinical testing, but realized that there were no clinically relevant adjuvants available that would support the strong CMI response needed. Since then the aim for the adjuvant research at Statens Serum Institut has been to provide adjuvants with distinct immunogenicity profiles correlating with protection for any given infectious disease. Two of the adjuvants CAF01 and CAF09 are currently being evaluated in human clinical trials. The purpose of this review is to give an overview of the immunocorrelates of those CAF adjuvants furthest in development. We further aim at giving an overview of the mechanism of action of the CAF adjuvants.

Entities: Disease Gene Species

Keywords: Adjuvant; CAF; Cationic; Immunocorrelates; MMG; TDB

Mesh：

Substances：

Year: 2018 PMID： 30396811 DOI： 10.1016/j.smim.2018.10.003

Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130

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Cited

24 in total

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Journal: J Immunol Date: 2020-05-01 Impact factor: 5.422

2. Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge.

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4. Monocytes Elicit a Neutrophil-Independent Th1/Th17 Response Upon Immunization With a Mincle-Dependent Glycolipid Adjuvant.

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6. Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge.

Authors: Nina Dieu Nhien Tran Nguyen; Anja W Olsen; Emma Lorenzen; Peter Andersen; Malene Hvid; Frank Follmann; Jes Dietrich
Journal: NPJ Vaccines Date: 2020-01-23 Impact factor: 7.344

Immunocorrelates of CAF family adjuvants.

1. CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection.

2. Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge.

Review 3. Advances in Infectious Disease Vaccine Adjuvants.

4. Monocytes Elicit a Neutrophil-Independent Th1/Th17 Response Upon Immunization With a Mincle-Dependent Glycolipid Adjuvant.

Review 5. Cationic Nanoparticle-Based Cancer Vaccines.

6. Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge.

7. Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate.

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9. New relationship of E2F1 and BNIP3 with caveolin-1 in lung cancer-associated fibroblasts.

10. Microfluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice.