Chelsea Anderson1, Yong-Moon Mark Park2, Frank Z Stanczyk3, Dale P Sandler2, Hazel B Nichols4. 1. Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina. 2. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. 3. Department of Obstetrics and Gynecology and Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California. 4. Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: hazel.nichols@unc.edu.
Abstract
OBJECTIVE: To study the associations between dietary factors and circulating antimüllerian hormone (AMH) concentrations among late premenopausal women. DESIGN: AMH concentrations were measured in serum samples collected at enrollment from 296 women (aged 35-45 years) in the Sister Study cohort. Usual dietary intakes in the past 12 months were assessed using a validated food frequency questionnaire. Dietary exposures of interest included macronutrients, dietary fat subtypes, fiber, and glycemic index. Multivariable linear regression was used to evaluate associations between dietary variables and serum AMH concentrations. We also used nutrient density models to examine isocaloric replacement of macronutrients. SETTING: Not applicable. PATIENTS: Women aged 35-45 years. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Serum AMH concentrations in nanograms per milliliter (ng/mL). RESULTS: AMH concentrations were positively associated with percentage of energy from carbohydrates (β per 5% calories = 0.141 [95% CI 0.023, 0.259]; P trend = .019), and inversely associated with percentage of energy from fat (β per 5% calories = -0.152 [95% CI -0.299, -0.004]; P trend = .044). In analyses of dietary fat subtypes, AMH decreased with increasing monounsaturated fatty acids (P trend = .082) and polyunsaturated fatty acids (P trend = .043), particularly ω-6 fatty acids (P trend = .044), whereas no strong trend was observed for saturated fatty acids. Protein and alcohol intake were not strongly associated with AMH. CONCLUSIONS: Our cross-sectional analyses in a sample of late premenopausal women suggest that dietary fat intake may be inversely associated with circulating AMH concentrations. Further research in prospective studies is warranted to evaluate dietary factors as potential modifiers of ovarian reserve.
OBJECTIVE: To study the associations between dietary factors and circulating antimüllerian hormone (AMH) concentrations among late premenopausal women. DESIGN:AMH concentrations were measured in serum samples collected at enrollment from 296 women (aged 35-45 years) in the Sister Study cohort. Usual dietary intakes in the past 12 months were assessed using a validated food frequency questionnaire. Dietary exposures of interest included macronutrients, dietary fat subtypes, fiber, and glycemic index. Multivariable linear regression was used to evaluate associations between dietary variables and serum AMH concentrations. We also used nutrient density models to examine isocaloric replacement of macronutrients. SETTING: Not applicable. PATIENTS: Women aged 35-45 years. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Serum AMH concentrations in nanograms per milliliter (ng/mL). RESULTS:AMH concentrations were positively associated with percentage of energy from carbohydrates (β per 5% calories = 0.141 [95% CI 0.023, 0.259]; P trend = .019), and inversely associated with percentage of energy from fat (β per 5% calories = -0.152 [95% CI -0.299, -0.004]; P trend = .044). In analyses of dietary fat subtypes, AMH decreased with increasing monounsaturated fatty acids (P trend = .082) and polyunsaturated fatty acids (P trend = .043), particularly ω-6 fatty acids (P trend = .044), whereas no strong trend was observed for saturated fatty acids. Protein and alcohol intake were not strongly associated with AMH. CONCLUSIONS: Our cross-sectional analyses in a sample of late premenopausal women suggest that dietary fat intake may be inversely associated with circulating AMH concentrations. Further research in prospective studies is warranted to evaluate dietary factors as potential modifiers of ovarian reserve.
Authors: Ana B Maldonado-Cárceles; Lidia Mínguez-Alarcón; Irene Souter; Audrey J Gaskins; Mariel Arvizu; Paige L Williams; Jennifer B Ford; Jorge E Chavarro Journal: Fertil Steril Date: 2020-07-22 Impact factor: 7.329
Authors: Ana B Maldonado-Cárceles; Makiko Mitsunami; Andrea Florio; Paige L Williams; Jennifer B Ford; Irene Souter; Jorge E Chavarro; Lidia Mínguez-Alarcón Journal: Fertil Steril Date: 2022-07 Impact factor: 7.490
Authors: Glenn E Palomaki; Bhanu Kalra; Tanya Kumar; Amita S Patel; Gopal Savjani; Laura C Torchen; Andrea Dunaif; Anthony Morrison; Geralyn M Lambert-Messerlian; Ajay Kumar Journal: Fertil Steril Date: 2020-03-05 Impact factor: 7.329
Authors: Maryam Kazemi; Brittany Y Jarrett; Heidi Vanden Brink; Annie W Lin; Kathleen M Hoeger; Steven D Spandorfer; Marla E Lujan Journal: Nutrients Date: 2020-06-30 Impact factor: 5.717
Authors: Ashley M Eskew; Bronwyn S Bedrick; Jorge E Chavarro; Joan K Riley; Emily S Jungheim Journal: Reprod Biol Endocrinol Date: 2022-02-19 Impact factor: 5.211
Authors: Tess V Clendenen; Wenzhen Ge; Karen L Koenig; Yelena Afanasyeva; Claudia Agnoli; Elizabeth Bertone-Johnson; Louise A Brinton; Farbod Darvishian; Joanne F Dorgan; A Heather Eliassen; Roni T Falk; Göran Hallmans; Susan E Hankinson; Judith Hoffman-Bolton; Timothy J Key; Vittorio Krogh; Hazel B Nichols; Dale P Sandler; Minouk J Schoemaker; Patrick M Sluss; Malin Sund; Anthony J Swerdlow; Kala Visvanathan; Mengling Liu; Anne Zeleniuch-Jacquotte Journal: J Clin Endocrinol Metab Date: 2021-10-21 Impact factor: 6.134