Literature DB >> 30394469

Pelargonidin-3-O-rutinoside as a novel α-glucosidase inhibitor for improving postprandial hyperglycemia.

Yang Xu1, Lianghua Xie, Jiahong Xie, Yu Liu, Wei Chen.   

Abstract

A novel strategy for the isolation of anthocyanins was developed by a combination of high-speed countercurrent chromatography (HSCCC) and HPLC techniques. Using this strategy, a novel α-glucosidase inhibitor (pelargonidin-3-O-rutinoside, a natural anthocyanin) was isolated from strawberries. Structural determinants for inhibition of α-glucosidase by Pg3R and the SAR of natural anthocyanins were revealed in detail by enzymatic kinetics and molecular docking analysis.

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Year:  2018        PMID： 30394469     DOI： 10.1039/c8cc07985d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

Review 1.  Anthocyanins as Antidiabetic Agents-In Vitro and In Silico Approaches of Preventive and Therapeutic Effects.

Authors:  Hélder Oliveira; Ana Fernandes; Natércia F Brás; Nuno Mateus; Victor de Freitas; Iva Fernandes
Journal:  Molecules       Date:  2020-08-21       Impact factor: 4.411

2.  Bound Polyphenols from Red Quinoa Prevailed over Free Polyphenols in Reducing Postprandial Blood Glucose Rises by Inhibiting α-Glucosidase Activity and Starch Digestion.

Authors:  Yu Zhang; Bing Bai; Yu Yan; Juan Liang; Xiao Guan
Journal:  Nutrients       Date:  2022-02-09       Impact factor: 5.717

3.  Extraction and Study of Hypoglycemic Constituents from Myrica rubra Pomace.

Authors:  Guoli Chang; Chenggang Cai; Yannan Xiang; Xiangjun Fang; Hailong Yang
Journal:  Molecules       Date:  2022-01-27       Impact factor: 4.411

4.  Two Myricetin-Derived Flavonols from Morella rubra Leaves as Potent α-Glucosidase Inhibitors and Structure-Activity Relationship Study by Computational Chemistry.

Authors:  Yilong Liu; Ruoqi Wang; Chuanhong Ren; Yifeng Pan; Jiajia Li; Xiaoyong Zhao; Changjie Xu; Kunsong Chen; Xian Li; Zhiwei Gao
Journal:  Oxid Med Cell Longev       Date:  2022-04-19       Impact factor: 7.310

5.  α-Glucosidase inhibitors from Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit: molecular docking and interaction mechanism of flavonols with different B-ring hydroxylations.

Authors:  Yilong Liu; Liuhuan Zhan; Chang Xu; Huamin Jiang; Changqing Zhu; Linxiao Sun; Chongde Sun; Xian Li
Journal:  RSC Adv       Date:  2020-08-10       Impact factor: 4.036

Review 6.  Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit.

Authors:  Yang Lu; Tao Bao; Jianling Mo; Jingdan Ni; Wei Chen
Journal:  J Zhejiang Univ Sci B       Date:  2021-06-15       Impact factor: 3.066

7.  Protective effect of chronic administration of pelargonidin on neuronal apoptosis and memory process in amyloid-beta-treated rats.

Authors:  Nazita Alisavari; Sara Soleimani-Asl; Mohammad Zarei; Nasrin Hashemi-Firouzi; Siamak Shahidi
Journal:  Avicenna J Phytomed       Date:  2021 Jul-Aug
  7 in total

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