I S Pradipta1, N Van't Boveneind-Vrubleuskaya2, O W Akkerman3, J W C Alffenaar4, E Hak5. 1. University of Groningen, Groningen Research Institute of Pharmacy, Unit of Pharmaco-Therapy, Epidemiology and -Economics (PTE2), the Netherlands; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia; University of Groningen, University Medical Centre Groningen, Department of Clinical Pharmacy and Pharmacology, the Netherlands. Electronic address: ivanpradipta@unpad.ac.id. 2. University of Groningen, University Medical Centre Groningen, Department of Clinical Pharmacy and Pharmacology, the Netherlands; Department of Public Health TB Control, Metropolitan Public Health Services, The Hague, the Netherlands. 3. University of Groningen, University Medical Centre Groningen, Department of Pulmonary Diseases and Tuberculosis, Groningen, the Netherlands; University of Groningen, University Medical Centre Groningen, Tuberculosis Centre Beatrixoord, Haren, the Netherlands. 4. University of Groningen, University Medical Centre Groningen, Department of Clinical Pharmacy and Pharmacology, the Netherlands. 5. University of Groningen, Groningen Research Institute of Pharmacy, Unit of Pharmaco-Therapy, Epidemiology and -Economics (PTE2), the Netherlands.
Abstract
OBJECTIVES: We evaluated treatment outcomes and predictors for poor treatment outcomes for tuberculosis (TB) among native- and foreign-born patients with drug-susceptible TB (DSTB) in the Netherlands. METHODS: This retrospective cohort study included adult patients with DSTB treated from 2005 to 2015 from a nationwide exhaustive registry. Predictors for unsuccessful treatment outcomes (default and failure) and TB-associated mortality were analysed using multivariate logistic regression. RESULTS: Among 5674 identified cases, the cumulative incidence of unsuccessful treatment and mortality were 2.6% (n/N = 146/5674) and 2.0% (112/5674), respectively. Although most patients were foreign-born (71%; 4042/5674), no significant differences in these outcomes were observed between native- and foreign-born patients (p > 0.05). Significant predictors for unsuccessful treatment were aged 18-24 years (odds ratio (OR), 2.04; 95% CI 1.34-3.10), homelessness (OR, 2.56; 95% CI 1.16-5.63), prisoner status (OR, 5.39; 95% CI 2.90-10.05) and diabetes (OR, 2.02; 95% CI 1.03-3.97). Furthermore, predictors for mortality were aged 74-84 years (OR, 5.58; 95% CI 3.10-10.03) or ≥85 years (OR, 9.35, 95% CI 4.31-20.30), combined pulmonary and extra-pulmonary TB (OR, 4.97; 95% CI 1.42-17.41), central nervous system (OR, 120, 95% CI 34.43-418.54) or miliary TB (OR, 10.73, 95% CI 2.50-46.02), drug addiction (OR, 3.56; 95% CI 1.34-9.47) and renal insufficiency/dialysis (OR, 3.23; 95% CI 1.17-8.96). CONCLUSIONS: Native- and foreign-born patients exhibited similar TB treatment outcomes. To further reduce disease transmission and inhibit drug resistance, special attention should be given to high-risk patients.
OBJECTIVES: We evaluated treatment outcomes and predictors for poor treatment outcomes for tuberculosis (TB) among native- and foreign-bornpatients with drug-susceptible TB (DSTB) in the Netherlands. METHODS: This retrospective cohort study included adult patients with DSTB treated from 2005 to 2015 from a nationwide exhaustive registry. Predictors for unsuccessful treatment outcomes (default and failure) and TB-associated mortality were analysed using multivariate logistic regression. RESULTS: Among 5674 identified cases, the cumulative incidence of unsuccessful treatment and mortality were 2.6% (n/N = 146/5674) and 2.0% (112/5674), respectively. Although most patients were foreign-born (71%; 4042/5674), no significant differences in these outcomes were observed between native- and foreign-bornpatients (p > 0.05). Significant predictors for unsuccessful treatment were aged 18-24 years (odds ratio (OR), 2.04; 95% CI 1.34-3.10), homelessness (OR, 2.56; 95% CI 1.16-5.63), prisoner status (OR, 5.39; 95% CI 2.90-10.05) and diabetes (OR, 2.02; 95% CI 1.03-3.97). Furthermore, predictors for mortality were aged 74-84 years (OR, 5.58; 95% CI 3.10-10.03) or ≥85 years (OR, 9.35, 95% CI 4.31-20.30), combined pulmonary and extra-pulmonary TB (OR, 4.97; 95% CI 1.42-17.41), central nervous system (OR, 120, 95% CI 34.43-418.54) or miliary TB (OR, 10.73, 95% CI 2.50-46.02), drug addiction (OR, 3.56; 95% CI 1.34-9.47) and renal insufficiency/dialysis (OR, 3.23; 95% CI 1.17-8.96). CONCLUSIONS: Native- and foreign-bornpatients exhibited similar TB treatment outcomes. To further reduce disease transmission and inhibit drug resistance, special attention should be given to high-risk patients.
Authors: Ivan S Pradipta; Natasha Van't Boveneind-Vrubleuskaya; Onno W Akkerman; Jan-Willem C Alffenaar; Eelko Hak Journal: Antimicrob Resist Infect Control Date: 2019-07-12 Impact factor: 4.887
Authors: Ivan S Pradipta; Lusiana R Idrus; Ari Probandari; Irma Melyani Puspitasari; Prayudi Santoso; Jan-Willem C Alffenaar; Eelko Hak Journal: Front Pharmacol Date: 2022-03-25 Impact factor: 5.810
Authors: Marie Helleberg; Daniel Cho; Christina Ekenberg; Søren Sørensen; Marianne Rix; Finn Gustafsson; Allan Rasmussen; Michael Perch; Peter H S Andersen; Jens D Lundgren; Aase Bengaard Andersen Journal: Tuberc Res Treat Date: 2020-04-25