Arjen Mol1, Esmee M Reijnierse2, Phuong Thanh Silvie Bui Hoang3, Richard J A van Wezel4, Carel G M Meskers5, Andrea B Maier6. 1. Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Van der Boechorstraat 9, 1081 BT, Amsterdam, The Netherlands; Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Heijendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. Electronic address: a2.mol@vu.nl. 2. Department of Medicine and Aged Care, @AgeMelbourne, The University of Melbourne, The Royal Melbourne Hospital, City Campus, Level 6 North, 300 Grattan Street, Parkville, Victoria 3050, Australia. Electronic address: esmee.reijnierse@unimelb.edu.au. 3. Department of Medicine and Aged Care, @AgeMelbourne, The University of Melbourne, The Royal Melbourne Hospital, City Campus, Level 6 North, 300 Grattan Street, Parkville, Victoria 3050, Australia. Electronic address: phuongb@student.unimelb.edu.au. 4. Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Heijendaalseweg 135, 6525 AJ Nijmegen, The Netherlands; Biomedical Signals and Systems, Technical Medical Centre, University of Twente, Zuidhorst Building, P.O. Box 217, 7500 AE Enschede, The Netherlands. Electronic address: R.vanWezel@donders.ru.nl. 5. Department of Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam Movement Sciences, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: c.meskers@vumc.nl. 6. Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Van der Boechorstraat 9, 1081 BT, Amsterdam, The Netherlands; Department of Medicine and Aged Care, @AgeMelbourne, The University of Melbourne, The Royal Melbourne Hospital, City Campus, Level 6 North, 300 Grattan Street, Parkville, Victoria 3050, Australia. Electronic address: andrea.maier@unimelb.edu.au.
Abstract
BACKGROUND: Orthostatic hypotension (OH) may negatively affect physical functioning and aggravate morbidities, but existing evidence is contradictory. METHODS: MEDLINE (from 1946), PubMed (from 1966) and EMBASE databases (from 1947) were systematically searched for studies on the association of OH and physical functioning in older adults, categorized as: balance, gait characteristics, walking speed, Timed Up and Go time, handgrip strength (HGS), physical frailty, exercise tolerance, physical activity, activities of daily living (ADL), and performance on the Hoehn and Yahr scale (HY) and Unified Parkinson's Disease Rating Scale (UPDRS). Study quality was assessed using the Newcastle Ottawa Scale. RESULTS: Forty-two studies were included in the systematic review (29,421 individuals) and 29 studies in the meta-analyses (23,879 individuals). Sixteen out of 42 studies reported a significant association of OH with worse physical functioning. Meta-analysis showed a significant association of OH with impaired balance, ADL performance and HY/UPDRS III performance, but not with gait characteristics, mobility, walking speed, TUG, HGS, physical frailty, exercise tolerance, physical activity and UPDRS II performance. CONCLUSIONS: OH was associated with impaired balance, ADL performance and HY/UPDRS III performance, but not with other physical functioning categories. The results suggest that OH interventions could potentially improve some aspects of physical functioning.
BACKGROUND:Orthostatic hypotension (OH) may negatively affect physical functioning and aggravate morbidities, but existing evidence is contradictory. METHODS: MEDLINE (from 1946), PubMed (from 1966) and EMBASE databases (from 1947) were systematically searched for studies on the association of OH and physical functioning in older adults, categorized as: balance, gait characteristics, walking speed, Timed Up and Go time, handgrip strength (HGS), physical frailty, exercise tolerance, physical activity, activities of daily living (ADL), and performance on the Hoehn and Yahr scale (HY) and Unified Parkinson's Disease Rating Scale (UPDRS). Study quality was assessed using the Newcastle Ottawa Scale. RESULTS: Forty-two studies were included in the systematic review (29,421 individuals) and 29 studies in the meta-analyses (23,879 individuals). Sixteen out of 42 studies reported a significant association of OH with worse physical functioning. Meta-analysis showed a significant association of OH with impaired balance, ADL performance and HY/UPDRS III performance, but not with gait characteristics, mobility, walking speed, TUG, HGS, physical frailty, exercise tolerance, physical activity and UPDRS II performance. CONCLUSIONS: OH was associated with impaired balance, ADL performance and HY/UPDRS III performance, but not with other physical functioning categories. The results suggest that OH interventions could potentially improve some aspects of physical functioning.
Authors: Arjen Mol; Carel G M Meskers; Marit L Sanders; Martin Müller; Andrea B Maier; Richard J A van Wezel; Jurgen A H R Claassen; Jan Willem J Elting Journal: Eur J Appl Physiol Date: 2021-04-16 Impact factor: 3.078
Authors: Elena M Christopoulos; Jennifer Tran; Sarah L Hillebrand; Peter W Lange; Rebecca K Iseli; Carel G M Meskers; Andrea B Maier Journal: Int J Cardiol Hypertens Date: 2020-12-08
Authors: Arjen Mol; Lois Robin Nicolle Slangen; Marijke C Trappenburg; Esmee M Reijnierse; Richard J A van Wezel; Carel G M Meskers; Andrea B Maier Journal: J Am Heart Assoc Date: 2020-03-30 Impact factor: 5.501