Fast non-cholinergic depolarizing postsynaptic potentials in neurons of rat superior cervical ganglia.

After the blockade of cholinergic transmission, stimulation of the preganglionic sympathetic trunk elicited fast depolarizing postsynaptic potentials (PSPs) in rat superior cervical ganglia. At 50 min, their amplitude measured intracellularly was 6.9 +/- 1.7 mV and their duration 25.9 +/- 7.6 ms (mean +/- S.D., n = 9 ganglia). The extracellular electrical activity recorded from the postganglionic internal carotid nerve was monophasic and equal to 4.0 +/- 2.2% of the normal activity (mean +/- S.D., n = 12 ganglia). The effects on these PSPs of some postsynaptic receptor antagonists have been tested. Bicuculline decreased the amplitude of the PSPs as well as that of the monophasic extracellular activity, suggesting that GABA could mediate these non-cholinergic synaptic potentials.