Literature DB >> 30393445

An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A.

Arun K Ghosh1, Hui Lei1.   

Abstract

An enantioselective formal synthesis of taurospongin A has been achieved. The key steps involve chelation-controlled reductions of β-ketosulfoxide and β-hydroxy ketone intermediates and Sharpless asymmetric epoxidation to construct the tertiary alcohol stereoselectively.

Entities:  

Year:  2003        PMID： 30393445      PMCID： PMC6211187          DOI： 10.1016/S0957-4166(03)00040-5

Source DB:  PubMed          Journal:  Tetrahedron Asymmetry        ISSN： 0957-4166


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