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Literature DB >> 30393394

An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors.

Arun K Ghosh¹, Sean P McKee¹, Wayne J Thompson¹.

Abstract

An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described. This synthesis represents a practical and enantioselective entry to a range of other dipeptide isosteres, which are not limited to amino acid derived substituents.

Entities: Chemical Species

Year: 1991 PMID： 30393394 PMCID： PMC6214462 DOI： 10.1021/jo00023a009

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

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An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors.

Review 1. Renin-angiotensin system: biochemistry and mechanisms of action.

2. HTLV-III gag protein is processed in yeast cells by the virus pol-protease.

3. Diphenylphosphoryl azide. A new convenient reagent for a modified Curtus reaction and for the peptide synthesis.

4. Transition state analogues for enzyme catalysis.

5. An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

Review 6. Renin inhibitors.

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