Tomoko Kihara1, Masato Komatsu2, Toshiko Sakuma3, Yoshiki Mikami4, Koushou Takasu5, Yuki Nakashima6, Shinsuke Mochizuki6, Motoyoshi Maruo6. 1. Department of Obstetrics and Gynecology, Hyogo Prefectural Kaibara Hospital, Tanba, Japan. Electronic address: tomosuke_usababy@yahoo.com. 2. Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan. 3. Department of Diagnostic Pathology, Hyogo Cancer Center, Akashi, Japan. 4. Department of Diagnostic Pathology, Kumamoto University, Kumamoto, Japan. 5. Department of Diagnostic Pathology, Hyogo Prefectural Kaibara Hospital, Tanba, Japan. 6. Department of Obstetrics and Gynecology, Hyogo Prefectural Kaibara Hospital, Tanba, Japan.
Abstract
BACKGROUND: The presence of anaplastic and sarcomatoid components in ovarian mucinous carcinoma is extremely rare. CASE: A 64-year-old woman underwent radical surgery for right ovarian cancer. Pathological examination showed mucinous adenocarcinoma with a focal mural nodule of anaplastic and sarcomatoid carcinoma (FIGO stage IIB). She underwent adjuvant chemotherapy but developed severe respiratory failure and died after 9 months. Autopsy showed that the bilateral pulmonary parenchyma was filled with a multinodular hemorrhagic mass, and the cardiac wall had a massive invasive lesion. Histopathological examination of the lung and myocardium revealed diffuse invasion of the anaplastic carcinoma component with infiltrating osteoclastic giant cells. CONCLUSION: This case is very rare, and the clinical management of anaplastic carcinoma arising in mucinous neoplasms remains challenging.
BACKGROUND: The presence of anaplastic and sarcomatoid components in ovarian mucinous carcinoma is extremely rare. CASE: A 64-year-old woman underwent radical surgery for right ovarian cancer. Pathological examination showed mucinous adenocarcinoma with a focal mural nodule of anaplastic and sarcomatoid carcinoma (FIGO stage IIB). She underwent adjuvant chemotherapy but developed severe respiratory failure and died after 9 months. Autopsy showed that the bilateral pulmonary parenchyma was filled with a multinodular hemorrhagic mass, and the cardiac wall had a massive invasive lesion. Histopathological examination of the lung and myocardium revealed diffuse invasion of the anaplastic carcinoma component with infiltrating osteoclastic giant cells. CONCLUSION: This case is very rare, and the clinical management of anaplastic carcinoma arising in mucinous neoplasms remains challenging.