| Literature DB >> 3039258 |
F Caligaris-Cappio, L Bergui, G Rege-Cambrin, L Tesio, N Migone, F Malavasi.
Abstract
A lymphoid cell line was established from a patient with B-cell chronic lymphocytic leukaemia (B-CLL) by infecting blood lymphocytes with Epstein-Barr virus (EBV). Immunoglobulin gene rearrangement studies and the presence of a chromosome marker (isochromosome 17q) provided the formal proof that the line has originated from the neoplastic B cells. The morphology and phenotype indicate that the EBV-induced cell line has reached a plasma cell-like stage of differentiation.Entities:
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Year: 1987 PMID： 3039258 DOI： 10.1016/0145-2126(87)90029-4
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156