[Recommendation for the substantial choice between various nonsteroidal antiinflammatory drugs based on their safety profile].

Nonsteroidal antiinflammatory drugs are the most commonly used painkillers. Both analgetic and antiinflammatory effects of these medications are important in the treatment of rheumatic diseases. Despite their well-recognized efficacy, professional societies recommend using nonsteroidal antiinflammatory drugs with caution, balancing the various potential gastrointestinal, cardiovascular and renal adverse events. Clinicians should consider advanced age and history of concomitant diseases even in younger patients when considering treatment choice. As our Hungarian society is aging, prescribers must be aware of the basic pharmacodynamics and pharmacokinetics of nonsteroidal antiinflammatory drugs as well as drug interactions and potential adverse effects should be taken into consideration when using them according to the latest professional guidelines. Orv Hetil. 2018; 159(44): 1783-1788.