Andrea Correa-Pérez1, Iosef Abraha2, Antonio Cherubini2, Avril Collinson3, Dominique Dardevet4, Lisette C P G M de Groot5, Marian A E de van der Schueren6, Antje Hebestreit7, Mary Hickson3, Javier Jaramillo-Hidalgo8, Isabel Lozano-Montoya9, Denis O'Mahony10, Roy L Soiza11, Marjolein Visser12, Dorothee Volkert13, Maike Wolters7, Alfonso J Cruz Jentoft9. 1. Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain. Electronic address: Andrea.correa@salud.madrid.org. 2. Geriatria, Accettazione geriatrica e Centro di ricerca per l'invecchiamento, Italian National Research Center on Aging (IRCCS- INRCA), Ancona, Italy. 3. Institute of Health and Community, University of Plymouth, United Kingdom. 4. Université Clermont Auvergne, INRA, UNH, Centre de Recherche en Nutrition Humaine (CRNH), Clermont-Ferrand, France. 5. Division of Human Nutrition and Health, Wageningen University. Wageningen, the Netherlands. 6. Department of Nutrition and health, HAN University of Applied Sciences, Nijmegen, Department of Nutrition and Dietetics, VU University Medical Center, Amsterdam, the Netherlands. 7. Leibniz Institute for Prevention Research and Epidemiology - BIPS. Bremen, Germany. 8. Servicio de Geriatría, Hospital Central de la Cruz Roja San José y Santa Adela, Madrid, Spain. 9. Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain. 10. Department of Geriatric Medicine, Cork University Hospital, Cork, Ireland. 11. Department of Medicine for the Elderly, NHS Grampian, Aberdeen, United Kingdom. 12. Department of Health Sciences, Vrije Universiteit Amsterdam, the Nederlands. 13. Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nuremberg, Germany.
Abstract
INTRODUCTION: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.
INTRODUCTION: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.
Authors: Lisa Söderström; Andreas Rosenblad; Leif Bergkvist; Hanna Frid; Eva Thors Adolfsson Journal: Ups J Med Sci Date: 2020-05-02 Impact factor: 2.384
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Authors: Roisin F O'Neill; Lorraine Brennan; Federica Prinelli; Giuseppe Sergi; Caterina Trevisan; Lisette C P G M De Groot; Dorothee Volkert; Stefania Maggi; Marianna Noale; Silvia Conti; Fulvio Adorni; Jayne V Woodside; Michelle C McKinley; Bernadette McGuinness; Chris Cardwell; Claire T McEvoy Journal: Nutr Bull Date: 2022-07-20