Literature DB >> 30391747

PPARδ agonist enhances colitis-associated colorectal cancer.

Danya Zhou1, Jianhua Jin2, Qian Liu2, Juanjuan Shi3, Yongzhong Hou4.   

Abstract

As a nuclear receptor, peroxisome proliferator-activated receptor-δ (PPARδ) plays a critical role in regulating inflammation and cancer, while it is still unclear the mechanism of PPARδ agonist GW501516 on colitis-associated colorectal cancer. Here we found that GW501516 significantly enhanced colitis-associated colorectal cancer in AOM/DSS-induced mice. In addition, PPARδ agonist GW501516 enhanced pro-inflammatory gene expressions (COX-2, IL-6, IL-8 and MCP-1) in inflamed colon. Further analysis showed that GW501516 increased the expressions of Glut1 and SLC1A5 in colon cancer cells as well as AOM/DSS-induced colorectal tumors. These findings revealed a new mechanism of PPARδ agonist GW501516-mediated colitis-associated colorectal cancer.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Agonist; Colitis-associated colorectal cancer; GW501516; PPARδ

Mesh：

Substances：

Year:  2018        PMID： 30391747     DOI： 10.1016/j.ejphar.2018.10.050

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

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Authors:  Nicole Wagner; Kay-Dietrich Wagner
Journal:  Cells       Date:  2022-08-05       Impact factor: 7.666

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Journal:  Mol Genet Genomic Med       Date:  2019-12-20       Impact factor: 2.183

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Authors:  Miao Chen; Weimin Lin; Rui Ye; Jianru Yi; Zhihe Zhao
Journal:  Front Cell Dev Biol       Date:  2021-11-26

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Authors:  Wei Han; Nan Wang; Rui Kong; Wen Bao; Jie Lu
Journal:  J Transl Med       Date:  2022-02-12       Impact factor: 5.531

6.  PPARβ/δ Augments IL-1β-Induced COX-2 Expression and PGE2 Biosynthesis in Human Mesangial Cells via the Activation of SIRT1.

Authors:  Yaqing Li; Rong Cao; Tingting Gu; Cong Cao; Tingyue Chen; Youfei Guan; Xiaoyan Zhang
Journal:  Metabolites       Date:  2022-06-27

Review 7.  PPAR Beta/Delta and the Hallmarks of Cancer.

Authors:  Nicole Wagner; Kay-Dietrich Wagner
Journal:  Cells       Date:  2020-05-04       Impact factor: 6.600

8.  Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation.

Authors:  Lijie Liu; Hanjing Gao; Tao Wen; Tao Gu; Shuang Zhang; Zhiyong Yuan
Journal:  Pharm Biol       Date:  2021-12       Impact factor: 3.503
  8 in total

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