Mariam M Mirambo1, Said Aboud2, Mtebe Majigo2, Uwe Groβ3, Stephen E Mshana4. 1. Department of Microbiology and Immunology, Weill Bugando School of Medicine, P.O. Box 1464, Mwanza, Tanzania. 2. Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania. 3. Institute of Medical Microbiology, Göttingen University Medical Centre, Germany. 4. Department of Microbiology and Immunology, Weill Bugando School of Medicine, P.O. Box 1464, Mwanza, Tanzania. Electronic address: Stephen72mshana@gmail.com.
Abstract
OBJECTIVE: This study investigated the adverse pregnancy outcomes among pregnant women with acute Rubella infections in the city of Mwanza, Tanzania. METHODS: A longitudinal study was conducted between 2014 and 2016 among pregnant women attending antenatal clinics. Women were screened for Rubella IgG and IgM antibodies using enzyme immunoassay (EIA). IgM seropositive pregnant women were followed up until the end of the pregnancy to determine Congenital Rubella Syndrome, congenital infections and other pregnancy outcomes. RESULTS: The median age of 685 enrolled pregnant women was 23 (IQR: 19-27) years. A total of 629(91.8%) were Rubella IgG seropositive while 61 (8.9%) were IgM seropositive. The IgM seropositivity was found to decrease significantly from first trimester to third trimester, p<0.001. Forty six (83.6%) of 55 Rubella IgM seropositive women had adverse pregnancy outcomes and 6 (10.9%) delivered neonates with CRS, making the overall incidence of CRS to be 6/685 (0.87%). First trimester IgM seropositive women had significantly higher adverse pregnancy outcomes than those in second/third trimesters (70.4% vs. 35.7, p=0.01). CONCLUSION: There is one case of CRS in every 100 pregnancies necessitating additional strategies to reach a goal of elimination of CRS in developing countries.
OBJECTIVE: This study investigated the adverse pregnancy outcomes among pregnant women with acute Rubella infections in the city of Mwanza, Tanzania. METHODS: A longitudinal study was conducted between 2014 and 2016 among pregnant women attending antenatal clinics. Women were screened for Rubella IgG and IgM antibodies using enzyme immunoassay (EIA). IgM seropositive pregnant women were followed up until the end of the pregnancy to determine Congenital Rubella Syndrome, congenital infections and other pregnancy outcomes. RESULTS: The median age of 685 enrolled pregnant women was 23 (IQR: 19-27) years. A total of 629(91.8%) were Rubella IgG seropositive while 61 (8.9%) were IgM seropositive. The IgM seropositivity was found to decrease significantly from first trimester to third trimester, p<0.001. Forty six (83.6%) of 55 Rubella IgM seropositive women had adverse pregnancy outcomes and 6 (10.9%) delivered neonates with CRS, making the overall incidence of CRS to be 6/685 (0.87%). First trimester IgM seropositive women had significantly higher adverse pregnancy outcomes than those in second/third trimesters (70.4% vs. 35.7, p=0.01). CONCLUSION: There is one case of CRS in every 100 pregnancies necessitating additional strategies to reach a goal of elimination of CRS in developing countries.
Authors: Fausta Michael; Mariam M Mirambo; Dafrossa Lyimo; Furaha Kyesi; Delfina R Msanga; Georgina Joachim; Honest Nyaki; Richard Magodi; Delphius Mujuni; Florian Tinuga; Ngwegwe Bulula; Bonaventura Nestory; Dhamira Mongi; Ahmed Makuwani; Betina Katembo; William Mwengee; Alex Mphuru; Nassor Mohamed; David Kayabu; Helmut Nyawale; Eveline T Konje; Stephen E Mshana Journal: Vaccines (Basel) Date: 2022-07-27
Authors: Jaspreet Toor; Susy Echeverria-Londono; Xiang Li; Kaja Abbas; Emily D Carter; Hannah E Clapham; Andrew Clark; Margaret J de Villiers; Kirsten Eilertson; Matthew Ferrari; Ivane Gamkrelidze; Timothy B Hallett; Wes R Hinsley; Daniel Hogan; John H Huber; Michael L Jackson; Kevin Jean; Mark Jit; Andromachi Karachaliou; Petra Klepac; Alicia Kraay; Justin Lessler; Xi Li; Benjamin A Lopman; Tewodaj Mengistu; C Jessica E Metcalf; Sean M Moore; Shevanthi Nayagam; Timos Papadopoulos; T Alex Perkins; Allison Portnoy; Homie Razavi; Devin Razavi-Shearer; Stephen Resch; Colin Sanderson; Steven Sweet; Yvonne Tam; Hira Tanvir; Quan Tran Minh; Caroline L Trotter; Shaun A Truelove; Emilia Vynnycky; Neff Walker; Amy Winter; Kim Woodruff; Neil M Ferguson; Katy Am Gaythorpe Journal: Elife Date: 2021-07-13 Impact factor: 8.140