| Literature DB >> 3039140 |
M Bobek, I Kavai, E De Clercq.
Abstract
5-(2,2-Difluorovinyl)uracil (IV) was synthesized from 2,4-dimethoxy-5-bromopyrimidine by sequential formylation, difluoromethylenation, and removal of the 2- and 4-methyl groups. Condensation of the trimethylsilyl derivative of IV with protected D-erythro-pentofuranosyl chloride followed by separation of anomers and deblocking gave 5-(2,2-difluorovinyl)-2'-deoxyuridine (V). Compound V was active against herpes simplex virus type 1 (HSV-1) infection as well as tumor cells transformed by the HSV-1 thymidine kinase gene.Entities:
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Year: 1987 PMID： 3039140 DOI： 10.1021/jm00391a036
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446