Literature DB >> 30390809

Embryology of the Parathyroid Glands.

Kristen Peissig1, Brian G Condie1, Nancy R Manley2.   

Abstract

The parathyroid glands are essential for regulating calcium homeostasis in the body. The genetic programs that control parathyroid fate specification, morphogenesis, differentiation, and survival are only beginning to be delineated, but are all centered around a key transcription factor, GCM2. Mutations in the Gcm2 gene as well as in several other genes involved in parathyroid organogenesis have been found to cause parathyroid disorders in humans. Therefore, understanding the normal development of the parathyroid will provide insight into the origins of parathyroid disorders.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  GCM2; Organogenesis; PTH; Parathyroid; SHH

Mesh：

Substances：

Year:  2018        PMID： 30390809      PMCID： PMC6226091          DOI： 10.1016/j.ecl.2018.07.002

Source DB:  PubMed          Journal:  Endocrinol Metab Clin North Am        ISSN： 0889-8529            Impact factor:   4.741


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