Caroline Roduit1,2,3, Remo Frei2,4, Ruth Ferstl2,4, Susanne Loeliger1,2, Patrick Westermann4, Claudio Rhyner2,4, Elisa Schiavi2,4, Weronika Barcik2,4, Noelia Rodriguez-Perez4, Marcin Wawrzyniak2,4, Christophe Chassard5, Christophe Lacroix5, Elisabeth Schmausser-Hechfellner6, Martin Depner6, Erika von Mutius6,7, Charlotte Braun-Fahrländer8,9, Anne M Karvonen10, Pirkka V Kirjavainen10,11, Juha Pekkanen10,12, Jean-Charles Dalphin13, Josef Riedler14, Cezmi Akdis2,4, Roger Lauener2,3, Liam O'Mahony2,4,15. 1. University Children's Hospital Zurich, Zurich, Switzerland. 2. Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland. 3. Children's Hospital St Gallen, St Gallen, Switzerland. 4. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. 5. Department of Health Sciences and Technology, ETH-Zurich, Zurich, Switzerland. 6. Institute for Asthma and Allergy Prevention, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Munich, Germany. 7. Dr von Hauner Children's Hospital of Ludwig Maximilian University of Munich, Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany. 8. Swiss Tropical and Public Health Institute, Basel, Switzerland. 9. University of Basel, Basel, Switzerland. 10. Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland. 11. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. 12. Department of Public Health, University of Helsinki, Helsinki, Finland. 13. Department of Respiratory Disease, University of Besançon, UMR/CNRS 6249 Chrono-environment, University Hospital, Besançon, France. 14. Children's Hospital, Schwarzach, Austria. 15. Departments of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.
Abstract
BACKGROUND: Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short-chain fatty acids (SCFAs) are metabolites present in certain foods and are produced by microbes in the gut following fermentation of fibers. SCFAs have been shown to have anti-inflammatory properties in animal models. Our objective was to investigate the potential role of SCFAs in the prevention of allergy and asthma. METHODS: We analyzed SCFA levels by high-performance liquid chromatography (HPLC) in fecal samples from 301 one-year-old children from a birth cohort and examined their association with early life exposures, especially diet, and allergy and asthma later in life. Data on exposures and allergic diseases were collected by questionnaires. In addition, we treated mice with SCFAs to examine their effect on allergic airway inflammation. RESULTS: Significant associations between the levels of SCFAs and the infant's diet were identified. Children with the highest levels of butyrate and propionate (≥95th percentile) in feces at the age of one year had significantly less atopic sensitization and were less likely to have asthma between 3 and 6 years. Children with the highest levels of butyrate were also less likely to have a reported diagnosis of food allergy or allergic rhinitis. Oral administration of SCFAs to mice significantly reduced the severity of allergic airway inflammation. CONCLUSION: Our results suggest that strategies to increase SCFA levels could be a new dietary preventive option for allergic diseases in children.
BACKGROUND: Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short-chain fatty acids (SCFAs) are metabolites present in certain foods and are produced by microbes in the gut following fermentation of fibers. SCFAs have been shown to have anti-inflammatory properties in animal models. Our objective was to investigate the potential role of SCFAs in the prevention of allergy and asthma. METHODS: We analyzed SCFA levels by high-performance liquid chromatography (HPLC) in fecal samples from 301 one-year-old children from a birth cohort and examined their association with early life exposures, especially diet, and allergy and asthma later in life. Data on exposures and allergic diseases were collected by questionnaires. In addition, we treated mice with SCFAs to examine their effect on allergic airway inflammation. RESULTS: Significant associations between the levels of SCFAs and the infant's diet were identified. Children with the highest levels of butyrate and propionate (≥95th percentile) in feces at the age of one year had significantly less atopic sensitization and were less likely to have asthma between 3 and 6 years. Children with the highest levels of butyrate were also less likely to have a reported diagnosis of food allergy or allergic rhinitis. Oral administration of SCFAs to mice significantly reduced the severity of allergic airway inflammation. CONCLUSION: Our results suggest that strategies to increase SCFA levels could be a new dietary preventive option for allergic diseases in children.
Authors: Claire Healy; Natalia Munoz-Wolf; Janné Strydom; Lynne Faherty; Niamh C Williams; Sarah Kenny; Seamas C Donnelly; Suzanne M Cloonan Journal: Respir Res Date: 2021-04-29
Authors: Martin Depner; Diana Hazard Taft; Pirkka V Kirjavainen; Karen M Kalanetra; Anne M Karvonen; Stefanie Peschel; Elisabeth Schmausser-Hechfellner; Caroline Roduit; Remo Frei; Roger Lauener; Amandine Divaret-Chauveau; Jean-Charles Dalphin; Josef Riedler; Marjut Roponen; Michael Kabesch; Harald Renz; Juha Pekkanen; Freda M Farquharson; Petra Louis; David A Mills; Erika von Mutius; Markus J Ege Journal: Nat Med Date: 2020-11-02 Impact factor: 53.440
Authors: Kathleen A Lee-Sarwar; Rachel S Kelly; Jessica Lasky-Su; Robert S Zeiger; George T O'Connor; Megan T Sandel; Leonard B Bacharier; Avraham Beigelman; Sheryl L Rifas-Shiman; Vincent J Carey; Benjamin J Harshfield; Nancy Laranjo; Diane R Gold; Scott T Weiss; Augusto A Litonjua Journal: J Allergy Clin Immunol Pract Date: 2019-09-05
Authors: Jelle Folkerts; Frank Redegeld; Gert Folkerts; Bart Blokhuis; Mariska P M van den Berg; Marjolein J W de Bruijn; Wilfred F J van IJcken; Tobias Junt; See-Ying Tam; Stephen J Galli; Rudi W Hendriks; Ralph Stadhouders; Marcus Maurer Journal: Allergy Date: 2020-04-24 Impact factor: 13.146