Literature DB >> 3039014

Potency stability of recombinant (Serine-17) human interferon-beta.

J Geigert, D L Ziegler, B M Panschar, A A Creasey, C R Vitt.   

Abstract

The antiviral activity of Escherichia coli-derived (Serine-17) human interferon-beta, formulated with human serum albumin, is stable for 2 years when lyophilized and stored under refrigeration. This product shows an Arrhenius line fit for the stability of its activity when tested at multiple isothermal temperatures (25-80 degrees C). In both isothermal and nonisothermal elevated temperature studies, increasing the level of human serum albumin in the formulation results in increased thermal stability.

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Year:  1987        PMID: 3039014     DOI: 10.1089/jir.1987.7.203

Source DB:  PubMed          Journal:  J Interferon Res        ISSN: 0197-8357


  2 in total

1.  Is stability prediction possible for protein drugs? Denaturation kinetics of beta-galactosidase in solution.

Authors:  S Yoshioka; Y Aso; K Izutsu; S Kojima
Journal:  Pharm Res       Date:  1994-12       Impact factor: 4.200

2.  Inactivation kinetics of enzyme pharmaceuticals in aqueous solution.

Authors:  S Yoshioka; K Izutsu; Y Aso; Y Takeda
Journal:  Pharm Res       Date:  1991-04       Impact factor: 4.200

  2 in total

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