Alexis Panzer1, Sarah Dotters-Katz2, Marcela Smid3, Kim Boggess4, Tracy Manuck4. 1. Formerly of University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina, Currently of Columbia University, New York, New York. 2. Division of Maternal Fetal Medicine, Duke University, Durham, North Carolina. 3. Division of Maternal Fetal Medicine, University of Utah, Salt Lake City, Utah. 4. Division of Maternal Fetal Medicine University of North Carolina, Chapel Hill, North Carolina.
Abstract
OBJECTIVE: To identify factors associated with previable delivery in second trimester preterm rupture of membranes (PROM). STUDY DESIGN: We conducted a single-center retrospective cohort study of women with pregnancies complicated by second trimester PROM (14.0-21.9 weeks' gestation) from 2000 to 2015 who elected expectant pregnancy management and achieved at least 24 hours latency. Maternal characteristics and clinical factors were compared among pregnancies that reached viability (≥ 23.0 weeks) and pregnancies delivered before viability (< 23.0 weeks) using appropriate statistical methods. RESULTS: Of 73 pregnancies complicated by second trimester PROM, 49 (67%) delivered before viability. Maternal race, history of preterm birth, and tobacco use were similar between women who delivered < 23 weeks versus ≥ 23 weeks. Gestational age at PROM, cervical dilation > 1cm, Group B streptococcus carrier status, bacterial vaginosis, and chlamydial infection during pregnancy were similar between groups. Median time to delivery was significantly shorter in women who delivered < 23 weeks compared with those who reached ≥ 23 weeks (6 vs. 46 days, p < 0.01). CONCLUSION: Previable delivery occurred in the majority of women with second trimester PROM. No maternal or clinical factors were associated with delivery prior to viability. Counseling women with second trimester PROM should include the inability to determine which pregnancies will reach viability. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: To identify factors associated with previable delivery in second trimester preterm rupture of membranes (PROM). STUDY DESIGN: We conducted a single-center retrospective cohort study of women with pregnancies complicated by second trimester PROM (14.0-21.9 weeks' gestation) from 2000 to 2015 who elected expectant pregnancy management and achieved at least 24 hours latency. Maternal characteristics and clinical factors were compared among pregnancies that reached viability (≥ 23.0 weeks) and pregnancies delivered before viability (< 23.0 weeks) using appropriate statistical methods. RESULTS: Of 73 pregnancies complicated by second trimester PROM, 49 (67%) delivered before viability. Maternal race, history of preterm birth, and tobacco use were similar between women who delivered < 23 weeks versus ≥ 23 weeks. Gestational age at PROM, cervical dilation > 1cm, Group B streptococcus carrier status, bacterial vaginosis, and chlamydial infection during pregnancy were similar between groups. Median time to delivery was significantly shorter in women who delivered < 23 weeks compared with those who reached ≥ 23 weeks (6 vs. 46 days, p < 0.01). CONCLUSION: Previable delivery occurred in the majority of women with second trimester PROM. No maternal or clinical factors were associated with delivery prior to viability. Counseling women with second trimester PROM should include the inability to determine which pregnancies will reach viability. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Mia Kibel; Elizabeth Asztalos; Jon Barrett; Michael S Dunn; Carly Tward; Alex Pittini; Nir Melamed Journal: Obstet Gynecol Date: 2016-08 Impact factor: 7.661
Authors: B M Mercer; M Miodovnik; G R Thurnau; R L Goldenberg; A F Das; R D Ramsey; Y A Rabello; P J Meis; A H Moawad; J D Iams; J P Van Dorsten; R H Paul; S F Bottoms; G Merenstein; E A Thom; J M Roberts; D McNellis Journal: JAMA Date: 1997-09-24 Impact factor: 56.272