Literature DB >> 30388018

Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus.

Feng Xu1, Jungchul Kim1, Jacob Waldman1, Tao Wang1, Paul Devine1.   

Abstract

An efficient synthesis of grazoprevir is reported. Starting from four readily available building blocks, grazoprevir is prepared in 51% overall yield and >99.9% purity for pharmaceutical use.

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Year:  2018        PMID： 30388018     DOI： 10.1021/acs.orglett.8b03173

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  1 in total

1.  Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.

Authors:  Rohan Kalyan Rej; Changwei Wang; Jianfeng Lu; Mi Wang; Elyse Petrunak; Kaitlin P Zawacki; Donna McEachern; Chao-Yie Yang; Lu Wang; Ruiting Li; Krishnapriya Chinnaswamy; Bo Wen; Duxin Sun; Jeanne A Stuckey; Yunlong Zhou; Jianyong Chen; Guozhi Tang; Shaomeng Wang
Journal:  J Med Chem       Date:  2021-10-06       Impact factor: 7.446
  1 in total

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