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Literature DB >> 3038732

Absence of Y-specific DNA sequences in human 46,XX true hermaphrodites and in 45,X mixed gonadal dysgenesis.

F Waibel, G Scherer, M Fraccaro, T W Hustinx, J Weissenbach, J Wieland, A Mayerová, E Back, U Wolf.

Abstract

A search for Y-specific DNA sequences has been performed in a sample of seven 46,XX true hermaphrodites and one 45,X mixed gonadal dysgenesis case and compared with a sample of 11 XX males. Using six Y-specific DNA probes no hybridization signal was obtained in the hermaphrodite group; in contrast, all XX males gave a positive signal with at least one probe. This difference is statistically highly significant. We conclude that the aetiology of true hermaphroditism is different from that of the XX male syndrome. As all cases of the hermaphrodite group are positive for the serological sex-specific antigen (Sxs) it is concluded that this antigen can be present even in the absence of Y-specific DNA.

Entities: Disease Species

Mesh：

Substances：

Year: 1987 PMID： 3038732 DOI： 10.1007/BF00272440

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

27 in total

1. X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome.

Authors: M A Ferguson-Smith
Journal: Lancet Date: 1966-08-27 Impact factor: 79.321

2. Elicitation of a rapid and transient antibody response to H-Y antigen by intrasplenic immunization.

Authors: M P Bradley; B F Heslop
Journal: Transplantation Date: 1985-06 Impact factor: 4.939

3. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

4. A 45,X male with evidence of a translocation of Y euchromatin onto chromosome 15.

Authors: W Schempp; B Weber; A Serra; G Neri; A Gal; U Wolf
Journal: Hum Genet Date: 1985 Impact factor: 4.132

5. H-Y antigen, serologically detectable male antigen and sex determination.

Authors: W K Silvers; D L Gasser; E M Eicher
Journal: Cell Date: 1982-03 Impact factor: 41.582

6. Cell reorganization in vitro of heterosexual gonadal cocultures.

Authors: E Urban; M T Zenzes; U Müller; U Wolf
Journal: Differentiation Date: 1981 Impact factor: 3.880

7. Characterisation of a human Y chromosome repeated sequence and related sequences in higher primates.

Authors: H J Cooke; J Schmidtke; J R Gosden
Journal: Chromosoma Date: 1982 Impact factor: 4.316

8. A deletion map of the human Y chromosome based on DNA hybridization.

Authors: G Vergnaud; D C Page; M C Simmler; L Brown; F Rouyer; B Noel; D Botstein; A de la Chapelle; J Weissenbach
Journal: Am J Hum Genet Date: 1986-02 Impact factor: 11.025

9. Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids.

Authors: P Wieacker; K E Davies; H J Cooke; P L Pearson; R Williamson; S Bhattacharya; J Zimmer; H H Ropers
Journal: Am J Hum Genet Date: 1984-03 Impact factor: 11.025

10. Association of the H-Y male antigen with beta2-microglobulin on human lymphoid and differentiated mouse teratocarcinoma cell lines.

Authors: M Fellous; E Günther; R Kemler; J Wiels; R Berger; J L Guenet; H Jakob; F Jacob
Journal: J Exp Med Date: 1978-07-01 Impact factor: 14.307

21 in total

1. DNA analyses of XX and XX-hypospadiac males.

Authors: H Numabe; S Nagafuchi; Y Nakahori; T Tamura; H Kiuchi; M Namiki; N Kohda; Y Fukushima; H Fuse; M Kusano
Journal: Hum Genet Date: 1992-11 Impact factor: 4.132

2. Deletion of specific sequences or modification of centromeric chromatin are responsible for Y chromosome centromere inactivation.

Authors: P Maraschio; O Zuffardi; A Caiulo; E Dainotti; M Piantanida; H Rivera; R Tupler
Journal: Hum Genet Date: 1990-10 Impact factor: 4.132

Absence of Y-specific DNA sequences in human 46,XX true hermaphrodites and in 45,X mixed gonadal dysgenesis.

1. X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome.

2. Elicitation of a rapid and transient antibody response to H-Y antigen by intrasplenic immunization.

3. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

4. A 45,X male with evidence of a translocation of Y euchromatin onto chromosome 15.

5. H-Y antigen, serologically detectable male antigen and sex determination.

6. Cell reorganization in vitro of heterosexual gonadal cocultures.

7. Characterisation of a human Y chromosome repeated sequence and related sequences in higher primates.

8. A deletion map of the human Y chromosome based on DNA hybridization.

9. Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids.

10. Association of the H-Y male antigen with beta2-microglobulin on human lymphoid and differentiated mouse teratocarcinoma cell lines.

1. DNA analyses of XX and XX-hypospadiac males.

2. Deletion of specific sequences or modification of centromeric chromatin are responsible for Y chromosome centromere inactivation.

3. Deletion mapping of interval 6 of the human Y chromosome.

4. Molecular cytogenetic analysis of XX males using Y-specific DNA sequences, including SRY.

5. Genotype-phenotype correlations in XX males and their bearing on current theories of sex determination.

6. Molecular, cytogenetic, and clinical characterisation of six XX males including one prenatal diagnosis.

Review 7. Facts and considerations about sex-specific antigens.

8. Analysis of two 47,XXX males reveals X-Y interchange and maternal or paternal nondisjunction.

9. The complicated issue of human sex determination.

10. Investigation of the ZFY gene in XX true hermaphroditism and Swyer syndrome.