Literature DB >> 30387141

Melatonin, a toll-like receptor inhibitor: Current status and future perspectives.

Omid Reza Tamtaji1,2, Moein Mobini3, Russel J Reiter4, Abolfazl Azami5, Mohammad Saeed Gholami6,7, Zatollah Asemi8.   

Abstract

Toll-like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a beneficial agent in the treatment of inflammatory and immune disorders. Melatonin is potent anti-inflammatory hormone that regulates various molecular pathways. Withal, limited studies have evaluated the inhibitory role of melatonin on TLRs. This review summarizes the current knowledge related to the effects of melatonin on TLRs in some common inflammatory and immunity disorders.
© 2018 Wiley Periodicals, Inc.

Entities:  

Keywords:  inflammation; melatonin; myeloid differentiation factor 88; toll-like receptor

Mesh：

Substances：

Year:  2018        PMID： 30387141     DOI： 10.1002/jcp.27698

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  10 in total

1.  MyD88 in hepatic stellate cells promotes the development of alcoholic fatty liver via the AKT pathway.

Authors:  Yukun Li; Miaomiao Wei; Qi Yuan; Yu Liu; Tian Tian; Lingling Hou; Jinhua Zhang
Journal:  J Mol Med (Berl)       Date:  2022-06-16       Impact factor: 5.606

2.  Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease.

Authors:  Martin Hajsl; Alzbeta Hlavackova; Karolina Broulikova; Martin Sramek; Martin Maly; Jan E Dyr; Jiri Suttnar
Journal:  Metabolites       Date:  2020-05-19

Review 3.  Is Melatonin the Cornucopia of the 21st Century?

Authors:  Nadia Ferlazzo; Giulia Andolina; Attilio Cannata; Maria Giovanna Costanzo; Valentina Rizzo; Monica Currò; Riccardo Ientile; Daniela Caccamo
Journal:  Antioxidants (Basel)       Date:  2020-11-05

4.  Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses.

Authors:  Joanna Stefan; Tae-Kang Kim; Fiona Schedel; Zorica Janjetovic; David K Crossman; Kerstin Steinbrink; Radomir M Slominski; Jaroslaw Zmijewski; Meri K Tulic; Russel J Reiter; Konrad Kleszczyński; Andrzej T Slominski
Journal:  Antioxidants (Basel)       Date:  2021-04-17

Review 5.  Protective Role of Melatonin and Its Metabolites in Skin Aging.

Authors:  Georgeta Bocheva; Radomir M Slominski; Zorica Janjetovic; Tae-Kang Kim; Markus Böhm; Kerstin Steinbrink; Russel J Reiter; Konrad Kleszczyński; Andrzej T Slominski
Journal:  Int J Mol Sci       Date:  2022-01-22       Impact factor: 5.923

6.  Melatonin as an immunomodulator in children with Down syndrome.

Authors:  Dean Huggard; Lynne Kelly; Amy Worrall; Eleanor Gallagher; Lida Fallah; Lucas Lu Yoo; Fiona McGrane; Niamh Lagan; Edna Roche; Joanne Balfe; Derek G Doherty; Eleanor J Molloy
Journal:  Pediatr Res       Date:  2021-08-16       Impact factor: 3.953

Review 7.  Melatonin Synthesis and Function: Evolutionary History in Animals and Plants.

Authors:  Dake Zhao; Yang Yu; Yong Shen; Qin Liu; Zhiwei Zhao; Ramaswamy Sharma; Russel J Reiter
Journal:  Front Endocrinol (Lausanne)       Date:  2019-04-17       Impact factor: 5.555

8.  Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling.

Authors:  Seung Won Kim; Soochan Kim; Mijeong Son; Jae Hee Cheon; Young Sook Park
Journal:  Sci Rep       Date:  2020-02-10       Impact factor: 4.379

9.  The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle.

Authors:  Ramy Ka Sayed; Marisol Fernández-Ortiz; José Fernández-Martínez; Paula Aranda Martínez; Ana Guerra-Librero; César Rodríguez-Santana; Tomás de Haro; Germaine Escames; Darío Acuña-Castroviejo; Iryna Rusanova
Journal:  Antioxidants (Basel)       Date:  2021-03-27

Review 10.  The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy.

Authors:  Eva Ramos; Francisco López-Muñoz; Emilio Gil-Martín; Javier Egea; Iris Álvarez-Merz; Sakshi Painuli; Prabhakar Semwal; Natália Martins; Jesús M Hernández-Guijo; Alejandro Romero
Journal:  Antioxidants (Basel)       Date:  2021-07-20
  10 in total

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