| Literature DB >> 3038667 |
R A Barraco, D R Marcantonio, J W Phillis, W R Campbell.
Abstract
The dose-response effects of adenosine and its analogs on cardiovascular parameters were examined in rats following intravenous administration. 5'-N-ethylcarboxamidoadenosine (NECA) was by far the most potent analog in reducing mean arterial blood (PA) pressure while N6-(3-pentyl)-adenosine exerted the most potent bradycardic action. The N6-substituted (S)-diastereoisomers were substantially less potent in reducing PA and heart rate than NECA and the N6-substituted (R)-diastereoisomers. The cardiovascular effects of adenosine analogs persist, to varying degrees, much longer than those of adenosine itself.Entities:
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Year: 1987 PMID： 3038667 DOI： 10.1016/0306-3623(87)90099-1
Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623