Literature DB >> 3038579

Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum.

J R Traynor, A D Corbett, H W Kosterlitz.   

Abstract

The opioid agonist and antagonist activities of diprenorphine have been tested in four in vitro bioassay preparations. Diprenorphine is an antagonist at delta-receptors in the hamster vas deferens, at mu-receptors in the rat vas deferens and at kappa-receptors in the rabbit vas deferens. In the guinea-pig ileum it is an antagonist at mu-receptors and an agonist at kappa-receptors.

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Year:  1987        PMID： 3038579     DOI： 10.1016/0014-2999(87)90185-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Poster communications.

Authors: 
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

2.  Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin.

Authors:  D M Dixon; J R Traynor
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

3.  Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors.

Authors:  Kathryn E Livingston; M Alexander Stanczyk; Neil T Burford; Andrew Alt; Meritxell Canals; John R Traynor
Journal:  Mol Pharmacol       Date:  2017-12-12       Impact factor: 4.436

4.  Opioid antagonist diprenorphine microinjected into parabrachial nucleus selectively inhibits vasopressin response to hypovolemic stimuli in the rat.

Authors:  Y Iwasaki; M B Gaskill; R Fu; C B Saper; G L Robertson
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

5.  Alkylation with beta-funaltrexamine suggests differences between mu-opioid receptor systems in guinea-pig brain and myenteric-plexus.

Authors:  T G Franklin; J R Traynor
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739

6.  Evidence for lack of modulation of mu-opioid agonist action by delta-opioid agonists in the mouse vas deferens and guinea-pig ileum.

Authors:  J Elliott; J R Traynor
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739

7.  Use of butorphanol and diprenorphine to counter respiratory impairment in the immobilised white rhinoceros (Ceratotherium simum).

Authors:  Leith C R Meyer; Andrea Fuller; Markus Hofmeyr; Peter Buss; Michele Miller; Anna Haw
Journal:  J S Afr Vet Assoc       Date:  2018-10-18       Impact factor: 1.474
  7 in total

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