Literature DB >> 3038540

Nucleotide sequence of the ARG3 gene of the yeast Saccharomyces cerevisiae encoding ornithine carbamoyltransferase. Comparison with other carbamoyltransferases.

R Huygen, M Crabeel, N Glansdorff.   

Abstract

The complete nucleotide sequence of the ARG3 structural gene encoding the monomer of the trimeric ornithine carbamoyltransferase (OTCase) (EC 2.1.3.3) has been determined. It consists of 338 codons with a corresponding molecular mass of 37842 Da. Comparing OTCases from Escherichia coli, yeast, Aspergillus, rat and man emphasizes peculiarities of the yeast enzyme but also brings to light an important degree of conservation between these proteins. Comparing the various OTCases with E. coli aspartate carbamoyltransferase (ATCase) (EC 2.1.3.2) confirms the evolutionary relationship previously noted between the two types of carbamoyltransferases and points to residues probably involved in catalysis and structural folding in OTCases.

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Year:  1987        PMID： 3038540     DOI： 10.1111/j.1432-1033.1987.tb13525.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  20 in total

1.  Immunological characterization of plant ornithine transcarbamylases.

Authors:  R D Slocum; C L Williamson; C A Poggenburg; M A Lynes
Journal:  Plant Physiol       Date:  1990       Impact factor: 8.340

2.  cDNA cloning of two isoforms of ornithine carbamoyltransferase from Canavalia lineata leaves and the effect of site-directed mutagenesis of the carbamoyl phosphate binding site.

Authors:  Y Lee; Y A Choi; I D Hwang; S G Kim; Y M Kwon
Journal:  Plant Mol Biol       Date:  2001-08       Impact factor: 4.076

3.  Origin, structure, and regulation of argK, encoding the phaseolotoxin-resistant ornithine carbamoyltransferase in Pseudomonas syringae pv. phaseolicola, and functional expression of argK in transgenic tobacco.

Authors:  E Hatziloukas; N J Panopoulos
Journal:  J Bacteriol       Date:  1992-09       Impact factor: 3.490

4.  Nucleotide sequence of the Bacillus subtilis argF gene encoding ornithine carbamoyltransferase.

Authors:  A Mountain; M C Smith; S Baumberg
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

5.  A novel missense mutation in exon 8 of the ornithine transcarbamylase gene in two unrelated male patients with mild ornithine transcarbamylase deficiency.

Authors:  A Hata; T Matsuura; C Setoyama; K Shimada; T Yokoi; I Akaboshi; I Matsuda
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

6.  An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells.

Authors:  J T Lee; R L Nussbaum
Journal:  J Clin Invest       Date:  1989-12       Impact factor: 14.808

7.  Identification of two new aberrant splicings in the ornithine carbamoyltransferase (OCT) gene in two patients with early and late onset OCT deficiency.

Authors:  T Matsuura; R Hoshide; S Komaki; K Kiwaki; F Endo; S Nakamura; T Jitosho; I Matsuda
Journal:  J Inherit Metab Dis       Date:  1995       Impact factor: 4.982

8.  Four novel gene mutations in five Japanese male patients with neonatal or late onset OTC deficiency: application of PCR-single-strand conformation polymorphisms for all exons and adjacent introns [corrected].

Authors:  T Matsuura; R Hoshide; C Setoyama; K Shimada; Y Hase; T Yanagawa; M Kajita; I Matsuda
Journal:  Hum Genet       Date:  1993-08       Impact factor: 4.132

9.  Single-strand conformational polymorphism and direct sequencing applied to carrier testing in families with ornithine transcarbamylase deficiency.

Authors:  M Y Tsai; R A Holzknecht; M Tuchman
Journal:  Hum Genet       Date:  1993-05       Impact factor: 4.132

10.  Characterization of point mutations in the same arginine codon in three unrelated patients with ornithine transcarbamylase deficiency.

Authors:  A Maddalena; J E Spence; W E O'Brien; R L Nussbaum
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808
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