Literature DB >> 3038337

Enhancement of mRNA nuclear transport by promoter elements.

P de la Peña, M Zasloff.   

Abstract

This report describes studies on the kinetics of herpes thymidine kinase (TK) mRNA transport in X. laevis oocytes as studied by microinjection and microdissection. We show that TK mRNA nuclear transport in this cell can be dramatically altered by introduction of specific DNA sequences into the nucleus. Introduction of DNA sequences encompassing the promoter results in enhancement, in trans, of a transport process that can deliver previously synthesized RNA to the cytoplasm. The report suggests that the promoter of a eukaryotic gene can functionally interact with the mechanism involved in mRNA nuclear transport.

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Year:  1987        PMID： 3038337     DOI： 10.1016/0092-8674(87)90034-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  16 in total

1.  Active beta-globin gene transcription occurs in methylated, DNase I-resistant chromatin of nonerythroid chicken cells.

Authors:  R Lois; L Freeman; B Villeponteau; H G Martinson
Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272

2.  Horizontal transmissible protection against myxomatosis and rabbit hemorrhagic disease by using a recombinant myxoma virus.

Authors:  J Bárcena; M Morales; B Vázquez; J A Boga; F Parra; J Lucientes; A Pagès-Manté; J M Sánchez-Vizcaíno; R Blasco; J M Torres
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

3.  The intron requirement for immunoglobulin gene expression is dependent upon the promoter.

Authors:  M S Neuberger; G T Williams
Journal:  Nucleic Acids Res       Date:  1988-07-25       Impact factor: 16.971

4.  Nucleotide sequence of the Serratia marcescens threonine operon and analysis of the threonine operon mutations which alter feedback inhibition of both aspartokinase I and homoserine dehydrogenase I.

Authors:  K Omori; Y Imai; S Suzuki; S Komatsubara
Journal:  J Bacteriol       Date:  1993-02       Impact factor: 3.490

5.  Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway.

Authors:  M Braddock; M Muckenthaler; M R White; A M Thorburn; J Sommerville; A J Kingsman; S M Kingsman
Journal:  Nucleic Acids Res       Date:  1994-12-11       Impact factor: 16.971

6.  Promoter control of translation in Xenopus oocytes.

Authors:  N Gunkel; M Braddock; A M Thorburn; M Muckenthaler; A J Kingsman; S M Kingsman
Journal:  Nucleic Acids Res       Date:  1995-02-11       Impact factor: 16.971

7.  Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication.

Authors:  B A Sullenger; T C Lee; C A Smith; G E Ungers; E Gilboa
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

8.  mRNA export correlates with activation of transcription in human subgroup C adenovirus-infected cells.

Authors:  U C Yang; W Huang; S J Flint
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

9.  Introns are essential for growth-regulated expression of the mouse thymidylate synthase gene.

Authors:  J Ash; Y Ke; M Korb; L F Johnson
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

10.  Cloning and expression of the thyrotropin-releasing hormone receptor from GH3 rat anterior pituitary cells.

Authors:  P de la Peña; L M Delgado; D del Camino; F Barros
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857
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