Feng Pan1, Graeme Jones2. 1. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia. Feng.Pan@utas.edu.au. 2. Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.
Abstract
PURPOSE OF REVIEW: Pain is the most prominent symptom in osteoarthritis. Pain experience is a complex and multifactorial phenomenon. This review, therefore, offers a brief overview of the literature on factors from main pain dimensions and summarizes current evidence for identifying pain phenotypes in knee osteoarthritis. RECENT FINDINGS: Peripheral structural damage has been traditionally considered a source of pain and this has strengthened with MRI studies; however, a discordance between structural damage and pain severity suggests individual variations in pain presentation which may be determined by genetic, environmental (obesity), psychological, and neurological factors. Each of the factors may play its role or intact with other factors to contribute to the variation which can partly explain the overall lack of treatment efficacy with the current "one-size-fits-all" treatment approach. Identifying pain phenotypes in knee osteoarthritis is promising to develop individualized treatments; however, the validity and reliability of osteoarthritis pain phenotypes have not been tested in clinical practice. Given the heterogeneity of osteoarthritis pain, peripheral, psychological, and neurological factors are considered key phenotypic dimensions in the identification of pain phenotypes. This new concept allows for patients' stratification for clinical trials, thus providing the potential for individualized interventions in patients with osteoarthritis pain.
PURPOSE OF REVIEW: Pain is the most prominent symptom in osteoarthritis. Pain experience is a complex and multifactorial phenomenon. This review, therefore, offers a brief overview of the literature on factors from main pain dimensions and summarizes current evidence for identifying pain phenotypes in knee osteoarthritis. RECENT FINDINGS: Peripheral structural damage has been traditionally considered a source of pain and this has strengthened with MRI studies; however, a discordance between structural damage and pain severity suggests individual variations in pain presentation which may be determined by genetic, environmental (obesity), psychological, and neurological factors. Each of the factors may play its role or intact with other factors to contribute to the variation which can partly explain the overall lack of treatment efficacy with the current "one-size-fits-all" treatment approach. Identifying pain phenotypes in knee osteoarthritis is promising to develop individualized treatments; however, the validity and reliability of osteoarthritis pain phenotypes have not been tested in clinical practice. Given the heterogeneity of osteoarthritis pain, peripheral, psychological, and neurological factors are considered key phenotypic dimensions in the identification of pain phenotypes. This new concept allows for patients' stratification for clinical trials, thus providing the potential for individualized interventions in patients with osteoarthritis pain.
Authors: Anne-Marie Malfait; Albert B Seymour; Feng Gao; Micky D Tortorella; Marie-Pierre Hellio Le Graverand-Gastineau; Linda S Wood; Michael Doherty; Sally Doherty; Weiya Zhang; Nigel K Arden; Frances L Vaughn; Paul E Leaverton; Tim D Spector; Deborah J Hart; Rose A Maciewicz; Kenneth R Muir; Rosalina Das; Robert E Sorge; Susanna G Sotocinal; Ara Schorscher-Petcu; Ana M Valdes; Jeffrey S Mogil Journal: Ann Rheum Dis Date: 2012-03-22 Impact factor: 19.103
Authors: Tuhina Neogi; Ali Guermazi; Frank Roemer; Michael C Nevitt; Joachim Scholz; Lars Arendt-Nielsen; Clifford Woolf; Jingbo Niu; Laurence A Bradley; Emily Quinn; Laura Frey Law Journal: Arthritis Rheumatol Date: 2016-03 Impact factor: 10.995
Authors: Marjolein J Peters; Linda Broer; Hanneke L D M Willemen; Gudny Eiriksdottir; Lynne J Hocking; Kate L Holliday; Michael A Horan; Ingrid Meulenbelt; Tuhina Neogi; Maria Popham; Carsten O Schmidt; Anushka Soni; Ana M Valdes; Najaf Amin; Elaine M Dennison; Niels Eijkelkamp; Tamara B Harris; Deborah J Hart; Albert Hofman; Frank J P M Huygen; Karen A Jameson; Gareth T Jones; Lenore J Launer; Hanneke J M Kerkhof; Marjolein de Kruijf; John McBeth; Margreet Kloppenburg; William E Ollier; Ben Oostra; Antony Payton; Fernando Rivadeneira; Blair H Smith; Albert V Smith; Lisette Stolk; Alexander Teumer; Wendy Thomson; André G Uitterlinden; Ke Wang; Sophie H van Wingerden; Nigel K Arden; Cyrus Cooper; David Felson; Vilmundur Gudnason; Gary J Macfarlane; Neil Pendleton; P Eline Slagboom; Tim D Spector; Henry Völzke; Annemieke Kavelaars; Cornelia M van Duijn; Frances M K Williams; Joyce B J van Meurs Journal: Ann Rheum Dis Date: 2012-09-06 Impact factor: 19.103
Authors: Johanna E Vriezekolk; Yvonne A S Peters; Monique A H Steegers; Esmeralda N Blaney Davidson; Cornelia H M van den Ende Journal: Rheumatol Adv Pract Date: 2022-03-02