Literature DB >> 30381909

In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds.

Eleni Sioriki1, Ronan Lordan2, Fady Nahra1, Kristof van Hecke1, Ioannis Zabetakis2, Steven P Nolan1,3.   

Abstract

The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2 ] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2 ] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  N-heterocyclic carbenes; anti-atherogenic activity; atheromatosis; aurates; platelet-activating factor

Mesh：

Substances：

Year:  2018        PMID： 30381909     DOI： 10.1002/cmdc.201800601

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  6 in total

Review 1.  The Potential Role of Dietary Platelet-Activating Factor Inhibitors in Cancer Prevention and Treatment.

Authors:  Ronan Lordan; Alexandros Tsoupras; Ioannis Zabetakis
Journal:  Adv Nutr       Date:  2019-01-01       Impact factor: 8.701

2.  Investigation of Platelet Aggregation in Atherosclerosis.

Authors:  Ronan Lordan; Alexandros Tsoupras; Ioannis Zabetakis
Journal:  Methods Mol Biol       Date:  2022

3.  Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function in vitro.

Authors:  Alexandros Tsoupras; Ioannis Zabetakis; Ronan Lordan
Journal:  MethodsX       Date:  2018-12-26

Review 4.  Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives.

Authors:  Ronan Lordan; Alexandros Tsoupras; Ioannis Zabetakis; Constantinos A Demopoulos
Journal:  Molecules       Date:  2019-12-03       Impact factor: 4.411

5.  Synthesis of Novel Thiazole Derivatives Bearing β-Amino Acid and Aromatic Moieties as Promising Scaffolds for the Development of New Antibacterial and Antifungal Candidates Targeting Multidrug-Resistant Pathogens.

Authors:  Dovilė Malūkaitė; Birutė Grybaitė; Rita Vaickelionienė; Giedrius Vaickelionis; Birutė Sapijanskaitė-Banevič; Povilas Kavaliauskas; Vytautas Mickevičius
Journal:  Molecules       Date:  2021-12-23       Impact factor: 4.411

6.  The Role of the Fused Ring in Bicyclic Triazolium Organocatalysts: Kinetic, X-ray, and DFT Insights.

Authors:  Jiayun Zhu; Inmaculada Moreno; Peter Quinn; Dmitry S Yufit; Lijuan Song; Claire M Young; Zhuan Duan; Andrew R Tyler; Paul G Waddell; Michael J Hall; Michael R Probert; Andrew D Smith; AnnMarie C O'Donoghue
Journal:  J Org Chem       Date:  2022-03-01       Impact factor: 4.354
  6 in total

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