Literature DB >> 30381425

The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen.

A Denise R Garcia1, Young-Goo Han2, Jason W Triplett3, W Todd Farmer4, Corey C Harwell5, Rebecca A Ihrie6.   

Abstract

Sonic Hedgehog (SHH) signaling has been most widely known for its role in specifying region and cell-type identity during embryonic morphogenesis. This mini-review accompanies a 2018 SFN mini-symposium that addresses an emerging body of research focused on understanding the diverse roles for Shh signaling in a wide range of contexts in neurodevelopment and, more recently, in the mature CNS. Such research shows that Shh affects the function of brain circuits, including the production and maintenance of diverse cell types and the establishment of wiring specificity. Here, we review these novel and unexpected functions and the unanswered questions regarding the role of SHH and its signaling pathway members in these cases.
Copyright © 2018 the authors 0270-6474/18/389338-08$15.00/0.

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Year:  2018        PMID： 30381425      PMCID： PMC6209836          DOI： 10.1523/JNEUROSCI.1662-18.2018

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  89 in total

1.  Bergmann glial AMPA receptors are required for fine motor coordination.

Authors:  Aiman S Saab; Alexander Neumeyer; Hannah M Jahn; Alexander Cupido; Antonia A M Šimek; Henk-Jan Boele; Anja Scheller; Karim Le Meur; Magdalena Götz; Hannah Monyer; Rolf Sprengel; Maria E Rubio; Joachim W Deitmer; Chris I De Zeeuw; Frank Kirchhoff
Journal:  Science       Date:  2012-07-05       Impact factor: 47.728

2.  Distribution of Smoothened at hippocampal mossy fiber synapses.

Authors:  Christelle Masdeu; Véronique Bernard; Hélène Faure; Elisabeth Traiffort; Martial Ruat
Journal:  Neuroreport       Date:  2007-03-05       Impact factor: 1.837

3.  Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons.

Authors:  Francesca Balordi; Gord Fishell
Journal:  J Neurosci       Date:  2007-05-30       Impact factor: 6.167

4.  Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.

Authors:  Corey C Harwell; Philip R L Parker; Steven M Gee; Ami Okada; Susan K McConnell; Anatol C Kreitzer; Arnold R Kriegstein
Journal:  Neuron       Date:  2012-03-21       Impact factor: 17.173

5.  Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury.

Authors:  Ina B Wanner; Mark A Anderson; Bingbing Song; Jaclynn Levine; Ana Fernandez; Zachary Gray-Thompson; Yan Ao; Michael V Sofroniew
Journal:  J Neurosci       Date:  2013-07-31       Impact factor: 6.167

6.  Boc is a receptor for sonic hedgehog in the guidance of commissural axons.

Authors:  Ami Okada; Frédéric Charron; Steves Morin; David S Shin; Karen Wong; Pierre J Fabre; Marc Tessier-Lavigne; Susan K McConnell
Journal:  Nature       Date:  2006-11-01       Impact factor: 49.962

7.  Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain.

Authors:  A Denise R Garcia; Ralitsa Petrova; Liane Eng; Alexandra L Joyner
Journal:  J Neurosci       Date:  2010-10-13       Impact factor: 6.167

8.  Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.

Authors:  Luisa Sánchez-Arrones; Francisco Nieto-Lopez; Cristina Sánchez-Camacho; M Isabel Carreres; Eloisa Herrera; Ami Okada; Paola Bovolenta
Journal:  J Neurosci       Date:  2013-05-15       Impact factor: 6.167

9.  Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation.

Authors:  John R Sims; Sae-Won Lee; Kamil Topalkara; Jianhua Qiu; Jian Xu; Zhipeng Zhou; Michael A Moskowitz
Journal:  Stroke       Date:  2009-09-17       Impact factor: 7.914

10.  Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling.

Authors:  W Todd Farmer; Therése Abrahamsson; Sabrina Chierzi; Christopher Lui; Cristian Zaelzer; Emma V Jones; Blandine Ponroy Bally; Gary G Chen; Jean-Francois Théroux; Jimmy Peng; Charles W Bourque; Frédéric Charron; Carl Ernst; P Jesper Sjöström; Keith K Murai
Journal:  Science       Date:  2016-02-19       Impact factor: 47.728
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  14 in total

Review 1.  Mitochondrial function in spinal cord injury and regeneration.

Authors:  Paula G Slater; Miguel E Domínguez-Romero; Maximiliano Villarreal; Verónica Eisner; Juan Larraín
Journal:  Cell Mol Life Sci       Date:  2022-04-13       Impact factor: 9.261

Review 2.  Neuroinflammation: Extinguishing a blaze of T cells.

Authors:  Nail Benallegue; Hania Kebir; Jorge I Alvarez
Journal:  Immunol Rev       Date:  2022-07-31       Impact factor: 10.983

Review 3.  The Cerebellum in Niemann-Pick C1 Disease: Mouse Versus Man.

Authors:  Maria Teresa Fiorenza; Piergiorgio La Rosa; Sonia Canterini; Robert P Erickson
Journal:  Cerebellum       Date:  2022-01-18       Impact factor: 3.648

4.  Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization.

Authors:  Steven A Hill; Andrew S Blaeser; Austin A Coley; Yajun Xie; Katherine A Shepard; Corey C Harwell; Wen-Jun Gao; A Denise R Garcia
Journal:  Elife       Date:  2019-06-13       Impact factor: 8.140

5.  C9C5 positive mature oligodendrocytes are a source of Sonic Hedgehog in the mouse brain.

Authors:  Linda Tirou; Mariagiovanna Russo; Helene Faure; Giuliana Pellegrino; Ariane Sharif; Martial Ruat
Journal:  PLoS One       Date:  2020-02-20       Impact factor: 3.240

Review 6.  Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development.

Authors:  Ian Groves; Marysia Placzek; Alexander G Fletcher
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2020-08-24       Impact factor: 6.237

7.  Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response.

Authors:  Francesca Antonelli; Arianna Casciati; Montserrat Belles; Noemi Serra; Maria Victoria Linares-Vidal; Carmela Marino; Mariateresa Mancuso; Simonetta Pazzaglia
Journal:  Int J Mol Sci       Date:  2021-11-22       Impact factor: 5.923

8.  A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling.

Authors:  Ellen C Gingrich; Kendra Case; A Denise R Garcia
Journal:  Neural Dev       Date:  2022-01-14       Impact factor: 3.842

9.  The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation.

Authors:  Nail Benallegue; Hania Kebir; Richa Kapoor; Alexis Crockett; Cen Li; Lara Cheslow; Mohamed S Abdel-Hakeem; James Gesualdi; Miles C Miller; E John Wherry; Molly E Church; M Andres Blanco; Jorge I Alvarez
Journal:  Brain       Date:  2021-07-28       Impact factor: 13.501

10.  GLI3 Is Required for OLIG2+ Progeny Production in Adult Dorsal Neural Stem Cells.

Authors:  Rebecca J Embalabala; Asa A Brockman; Amanda R Jurewicz; Jennifer A Kong; Kaitlyn Ryan; Cristina D Guinto; Arturo Álvarez-Buylla; Chin Chiang; Rebecca A Ihrie
Journal:  Cells       Date:  2022-01-10       Impact factor: 7.666
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