Hongge Sun1, Qigui Liu2, Xiaorong Wang2, Meng Li2, Yongjun Fan2, Guirong Song3, Ying Liu4. 1. Department of Health Statistics, School of Public Health, Dalian Medical University, Dalian, Liaoning, China; The Centers for Disease Control and Prevention of Molidawa Daur Autonomous Banner, Hulun Buir, Inner Mongolia, China. 2. Department of Health Statistics, School of Public Health, Dalian Medical University, Dalian, Liaoning, China. 3. Department of Health Statistics, School of Public Health, Dalian Medical University, Dalian, Liaoning, China. Electronic address: song465894280@163.com. 4. The Physical Examination Center of the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. Electronic address: dy2ytjzx@163.com.
Abstract
BACKGROUND: Although alanine aminotransferase (ALT) is well known to be associated with metabolic syndrome (MetS), prospective data on longitudinal increments in ALT activities and incident cases of MetS are limited. We analyzed the impact of longitudinal increments of ALT on MetS based on a health check-up population in China. METHODS: A total of 4491 subjects free of MetS who completed at least two annual health examinations during March 2010 to April 2016 were enrolled in this cohort study. The MetS was defined according to the Joint Interim Statement criteria 2009. The RRs of incident MetS were estimated by using the Cox model and the Joint model in R software. RESULTS: The cumulative incidence of MetS was 18.55% during the 7 years of follow-up. In the Cox model, the estimated RR of developing MetS was 1.751 (95% CI =1.532-2.000) for 1 unit augmented in LNALT-0 level. In the Joint model, the estimated RR of developing MetS was 3.626 (95% CI = 2.721-4.831) for 1 unit augmented in LNALT activity longitudinally. CONCLUSIONS: The longitudinal increment of individuals' ALT activity over time increased the incidence risk of MetS and the effects generated by longitudinal increments of ALT on MetS was higher than that generated by baseline ALT.
BACKGROUND: Although alanine aminotransferase (ALT) is well known to be associated with metabolic syndrome (MetS), prospective data on longitudinal increments in ALT activities and incident cases of MetS are limited. We analyzed the impact of longitudinal increments of ALT on MetS based on a health check-up population in China. METHODS: A total of 4491 subjects free of MetS who completed at least two annual health examinations during March 2010 to April 2016 were enrolled in this cohort study. The MetS was defined according to the Joint Interim Statement criteria 2009. The RRs of incident MetS were estimated by using the Cox model and the Joint model in R software. RESULTS: The cumulative incidence of MetS was 18.55% during the 7 years of follow-up. In the Cox model, the estimated RR of developing MetS was 1.751 (95% CI =1.532-2.000) for 1 unit augmented in LNALT-0 level. In the Joint model, the estimated RR of developing MetS was 3.626 (95% CI = 2.721-4.831) for 1 unit augmented in LNALT activity longitudinally. CONCLUSIONS: The longitudinal increment of individuals' ALT activity over time increased the incidence risk of MetS and the effects generated by longitudinal increments of ALT on MetS was higher than that generated by baseline ALT.