Literature DB >> 3038080

The antioxidant action of human extracellular fluids. Effect of human serum and its protein components on the inactivation of alpha 1-antiproteinase by hypochlorous acid and by hydrogen peroxide.

M Wasil, B Halliwell, D C Hutchison, H Baum.   

Abstract

The elastase-inhibitory capacity of purified human alpha 1-antiproteinase is inactivated by low concentrations of the myeloperoxidase-derived oxidant hypochlorous acid, but much higher concentrations are required to inhibit the elastase-inhibitory capacity of serum samples. The protective effect of serum appears to be largely due to albumin. High concentrations of H2O2 also inactivate the elastase-inhibitory capacity of alpha 1-antiproteinase, by a mechanism not involving formation of hydroxyl radicals. Serum offers protection against H2O2 inactivation of alpha 1-antiproteinase. The relevance of these results to the tissue damage produced by activated phagocytes is discussed.

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Year:  1987        PMID： 3038080      PMCID： PMC1147835          DOI： 10.1042/bj2430219

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  41 in total

1.  Oxidative inactivation of Escherichia coli by hypochlorous acid. Rates and differentiation of respiratory from other reaction sites.

Authors:  J M Albrich; J K Hurst
Journal:  FEBS Lett       Date:  1982-07-19       Impact factor: 4.124

2.  Production of superoxide, hydrogen peroxide and hydroxyl radicals by phagocytic cells: a cause of chronic inflammatory disease?

Authors:  B Halliwell
Journal:  Cell Biol Int Rep       Date:  1982-06

3.  Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine.

Authors:  J M Gutteridge; R Richmond; B Halliwell
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

4.  Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

Authors:  O I Aruoma; B Halliwell
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

5.  In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

Authors:  H Carp; A Janoff
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808

6.  Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.

Authors:  H Carp; A Janoff
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

7.  Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.

Authors:  R A Clark; P J Stone; A El Hag; J D Calore; C Franzblau
Journal:  J Biol Chem       Date:  1981-04-10       Impact factor: 5.157

8.  Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation.

Authors:  S J Weiss; R Klein; A Slivka; M Wei
Journal:  J Clin Invest       Date:  1982-09       Impact factor: 14.808

9.  Myeloperoxidase-halide-hydrogen peroxide antibacterial system.

Authors:  S J Klebanoff
Journal:  J Bacteriol       Date:  1968-06       Impact factor: 3.490

10.  Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.

Authors:  J M Albrich; C A McCarthy; J K Hurst
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205
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  18 in total

1.  Nitrite, a reactive nitrogen species, protects human alpha-2-macroglobulin from halogenated oxidant, HOCl.

Authors:  M Wasim Khan; Ashreeb Naqshbandi; Haseeb Zubair; Haseeb Ahsan; Shakil A Khan; Fahim H Khan
Journal:  Protein J       Date:  2010-05       Impact factor: 2.371

2.  Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase.

Authors:  O I Aruoma; B Halliwell
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

3.  The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of alpha 1-antiproteinase against inactivation by hypochlorous acid.

Authors:  M Wasil; B Halliwell; M Grootveld; C P Moorhouse; D C Hutchison; H Baum
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

Review 4.  Free radical ablation for the prevention of post-ischemic renal failure following renal transplantation.

Authors:  H J Schiller; K A Andreoni; G B Bulkley
Journal:  Klin Wochenschr       Date:  1991-12-15

5.  Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice.

Authors:  Eli C Lewis; Leland Shapiro; Owen J Bowers; Charles A Dinarello
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-10       Impact factor: 11.205

6.  Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo?

Authors:  O I Aruoma; M J Laughton; B Halliwell
Journal:  Biochem J       Date:  1989-12-15       Impact factor: 3.857

7.  An oxidation-resistant, recombinant alpha-1 antitrypsin produced in Nicotiana benthamiana.

Authors:  David Z Silberstein; Kalimuthu Karuppanan; Hnin Hnin Aung; Ching-Hsien Chen; Carroll E Cross; Karen A McDonald
Journal:  Free Radic Biol Med       Date:  2018-03-16       Impact factor: 7.376

8.  Protective effect of seminal plasma proteins on the degradation of ascorbic acid.

Authors:  L Liu; K Dabrowski; A Ciereszko
Journal:  Mol Cell Biochem       Date:  1995-07-05       Impact factor: 3.396

9.  Agents capable of eliminating reactive oxygen species. Catalase, WR-2721, or Cu(II)2(3,5-DIPS)4 decrease experimental colitis.

Authors:  A Keshavarzian; J Haydek; R Zabihi; M Doria; M D'Astice; J R Sorenson
Journal:  Dig Dis Sci       Date:  1992-12       Impact factor: 3.199

10.  L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities.

Authors:  M A Babizhayev; M C Seguin; J Gueyne; R P Evstigneeva; E A Ageyeva; G A Zheltukhina
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857
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