Havva Evrengül1, Selçuk Yüksel2, Mustafa Doğan3, Dolunay Gürses3, Harun Evrengül4. 1. Department of Pediatric Nephrology, Medical Faculty of Pamukkale University, Denizli, Turkey. 2. Department of Pediatric Rheumatology, Medical Faculty of Pamukkale University, Denizli, Turkey. 3. Department of Pediatric Cardiology, Medical Faculty of Pamukkale University, Denizli, Turkey. 4. Department of Cardiology, Medical Faculty of Pamukkale University, Denizli, Turkey.
Abstract
OBJECTIVES: This study aims to investigate if cardiac involvement may occur in children with familial Mediterranean fever (FMF) without cardiovascular symptoms by using heart rate recovery (HRR) and systolic blood pressure recovery (SBPR) parameters. PATIENTS AND METHODS: A total of 50 FMF patients (26 males, 24 females; mean age 151±33.4 month; range 60 to 216 month) and 30 healthy controls (18 males, 12 females; mean age 143±43.9 month; range 84 to 228 month) were included in the study. All patients were evaluated by echocardiography. All patients underwent a maximal graded exercise stress test. HRR and SBPR parameters were calculated. RESULTS: There was a significant decrease in HRR1 value in FMF group (p=0.03). SBPR1 and SPBR2 values were higher in FMF group compared to control group (0.96±0.12 vs 0.88±0.12 and 0.95±0.09 vs 0.91±0.11, respectively); and the high SBPR1 value was statistically significant (p=0.02). FMF presence had a negative correlation with HRR1 (r= -0.26, p=0.03) and a positive correlation with SBPR1 (r=0.29, p=0.02). There was a negative correlation of M694V homozygous mutation with HRR1 and HRR2 values (r= -0.43, p=0.004, r=-0.42, p=0.005). CONCLUSION: Cardiac involvement may occur in FMF patients without cardiovascular symptoms. Impaired SBPR and decreased HRR response may indicate increased cardiovascular risk in these patients despite normal exercise stress test results.
OBJECTIVES: This study aims to investigate if cardiac involvement may occur in children with familial Mediterranean fever (FMF) without cardiovascular symptoms by using heart rate recovery (HRR) and systolic blood pressure recovery (SBPR) parameters. PATIENTS AND METHODS: A total of 50 FMF patients (26 males, 24 females; mean age 151±33.4 month; range 60 to 216 month) and 30 healthy controls (18 males, 12 females; mean age 143±43.9 month; range 84 to 228 month) were included in the study. All patients were evaluated by echocardiography. All patients underwent a maximal graded exercise stress test. HRR and SBPR parameters were calculated. RESULTS: There was a significant decrease in HRR1 value in FMF group (p=0.03). SBPR1 and SPBR2 values were higher in FMF group compared to control group (0.96±0.12 vs 0.88±0.12 and 0.95±0.09 vs 0.91±0.11, respectively); and the high SBPR1 value was statistically significant (p=0.02). FMF presence had a negative correlation with HRR1 (r= -0.26, p=0.03) and a positive correlation with SBPR1 (r=0.29, p=0.02). There was a negative correlation of M694V homozygous mutation with HRR1 and HRR2 values (r= -0.43, p=0.004, r=-0.42, p=0.005). CONCLUSION: Cardiac involvement may occur in FMF patients without cardiovascular symptoms. Impaired SBPR and decreased HRR response may indicate increased cardiovascular risk in these patients despite normal exercise stress test results.
Authors: Z Ozbalkan; M A Ozturk; A M Onat; K Ureten; I C Haznedaroglu; S Kiraz; A I Ertenli; S Kirazli; M Calguneri Journal: Clin Exp Rheumatol Date: 2006 Sep-Oct Impact factor: 4.473
Authors: Uğur Canpolat; Muhammed Dural; Kudret Aytemir; Ali Akdoğan; Ergün Barış Kaya; Levent Sahiner; Ulvi Yalçin; Asena Gökçay Canpolat; Meral Calgüneri; Giray Kabakçi; Lale Tokgözoğlu; Ali Oto Journal: Auton Neurosci Date: 2011-11-21 Impact factor: 3.145