A Agodi1, M Barchitta1, F Auxilia2, S Brusaferro3, M M D'Errico4, M T Montagna5, C Pasquarella6, S Tardivo7, C Arrigoni8, L Fabiani9, P Laurenti10, A R Mattaliano11, G B Orsi12, R Squeri13, M V Torregrossa14, I Mura15. 1. Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Catania, Italy. 2. Department of Biomedical Sciences for Health, University of Milan, Milan, Italy. 3. Department of Medicine, University of Udine, Udine, Italy. 4. Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy. 5. Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy. 6. Department of Medicine and Surgery, University of Parma, Parma, Italy. 7. Department of Diagnostic and Public Health, University of Verona, Verona, Italy. 8. Department of Public Health, Experimental and Forensic Medicine, Unit of Hygiene, University of Pavia, Pavia, Italy. 9. Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. 10. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia; Institute of Public Health, Hygiene Section, Università Cattolica del Sacro Cuore, Roma, Italia. 11. ARNAS Garibaldi, Catania, Italy. 12. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. 13. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. 14. Department of Sciences for Health Promotion and Mother-Child Care "G. D'Alessandro", University of Palermo, Palermo, Italy. 15. Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Abstract
BACKGROUND: Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. STUDY DESIGN: Prospective multicenter study. METHODS: The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. RESULTS: During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. CONCLUSION: Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.
BACKGROUND:Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. STUDY DESIGN: Prospective multicenter study. METHODS: The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. RESULTS: During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. CONCLUSION: Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.
Authors: Robby Markwart; Hiroki Saito; Thomas Harder; Sara Tomczyk; Alessandro Cassini; Carolin Fleischmann-Struzek; Felix Reichert; Tim Eckmanns; Benedetta Allegranzi Journal: Intensive Care Med Date: 2020-06-26 Impact factor: 17.440
Authors: Martina Barchitta; Andrea Maugeri; Maria Clara La Rosa; Claudia La Mastra; Giuseppe Murolo; Antonella Agodi Journal: Antibiotics (Basel) Date: 2020-12-22
Authors: Francesco Triggiano; Giuseppina Caggiano; Marco Lopuzzo; Giusy Diella; Francesca Apollonio; Fabrizio Fasano; Maria Teresa Montagna Journal: Int J Environ Res Public Health Date: 2022-04-17 Impact factor: 4.614