Literature DB >> 30374498

Ruthenium-catalyzed C-H oxygenation of quinones by weak O-coordination for potent trypanocidal agents.

Gleiston G Dias1, Torben Rogge, Rositha Kuniyil, Claus Jacob, Rubem F S Menna-Barreto, Eufrânio N da Silva Júnior, Lutz Ackermann.   

Abstract

Ruthenium-catalysis enabled the C-5 selective C-H oxygenation of naphthoquinones, and also sets the stage for the site-selective introduction of a hydroxyl group into anthraquinones. A-ring modified naphthoquinoidal compounds represent an important class of bioactive quinones for which the present study encompasses the first C-H oxygenation strategy by weak O-coordination.

Entities:  

Year:  2018        PMID： 30374498     DOI： 10.1039/c8cc07572g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: redox and biological implications.

Authors:  Renata G Almeida; Wagner O Valença; Luísa G Rosa; Carlos A de Simone; Solange L de Castro; Juliana M C Barbosa; Daniel P Pinheiro; Carlos R K Paier; Guilherme G C de Carvalho; Claudia Pessoa; Marilia O F Goulart; Ammar Kharma; Eufrânio N da Silva Júnior
Journal:  RSC Med Chem       Date:  2020-07-13

2.  It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity.

Authors:  Daisy J B Lima; Renata G Almeida; Guilherme A M Jardim; Breno P A Barbosa; Augusto C C Santos; Wagner O Valença; Marcos R Scheide; Claudia C Gatto; Guilherme G C de Carvalho; Pedro M S Costa; Claudia Pessoa; Cynthia L M Pereira; Claus Jacob; Antonio L Braga; Eufrânio N da Silva Júnior
Journal:  RSC Med Chem       Date:  2021-08-12

3.  Rhoda-Electrocatalyzed Bimetallic C-H Oxygenation by Weak O-Coordination.

Authors:  Xuefeng Tan; Leonardo Massignan; Xiaoyan Hou; Johanna Frey; João C A Oliveira; Masoom Nasiha Hussain; Lutz Ackermann
Journal:  Angew Chem Int Ed Engl       Date:  2021-05-07       Impact factor: 15.336

4.  C-H Oxygenation Reactions Enabled by Dual Catalysis with Electrogenerated Hypervalent Iodine Species and Ruthenium Complexes.

Authors:  Leonardo Massignan; Xuefeng Tan; Tjark H Meyer; Rositha Kuniyil; Antonis M Messinis; Lutz Ackermann
Journal:  Angew Chem Int Ed Engl       Date:  2020-01-09       Impact factor: 15.336
  4 in total

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