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Literature DB >> 30374185

Mitochondrial disease: Eliminating mutant mitochondrial DNA.

Sarah Crunkhorn.

Abstract

Entities: Disease

Year: 2018 PMID： 30374185 DOI： 10.1038/nrd.2018.190

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

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2 in total

1. MitoTALEN reduces mutant mtDNA load and restores tRNA^Ala levels in a mouse model of heteroplasmic mtDNA mutation.

Authors: Sandra R Bacman; Johanna H K Kauppila; Claudia V Pereira; Nadee Nissanka; Maria Miranda; Milena Pinto; Sion L Williams; Nils-Göran Larsson; James B Stewart; Carlos T Moraes
Journal: Nat Med Date: 2018-09-24 Impact factor: 53.440

2. Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.

Authors: Payam A Gammage; Carlo Viscomi; Marie-Lune Simard; Ana S H Costa; Edoardo Gaude; Christopher A Powell; Lindsey Van Haute; Beverly J McCann; Pedro Rebelo-Guiomar; Raffaele Cerutti; Lei Zhang; Edward J Rebar; Massimo Zeviani; Christian Frezza; James B Stewart; Michal Minczuk
Journal: Nat Med Date: 2018-09-24 Impact factor: 53.440

2 in total

Mitochondrial disease: Eliminating mutant mitochondrial DNA.

1. MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.

2. Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.

1. MitoTALEN reduces mutant mtDNA load and restores tRNA^Ala levels in a mouse model of heteroplasmic mtDNA mutation.