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Literature DB >> 3037407

Vanadate inhibition of rat cerebral cortex Na+,K+-ATPase during postnatal development.

Abstract

The Na+,K+-ATPase activity and its response to vanadate inhibition was investigated in cerebral cortex homogenates of 7-, 12- and 18-day-old rats. The enzyme was inhibited by vanadate in a dose-dependent manner in all these age groups. Furthermore, there was a different sensitivity towards vanadate during postnatal development; the concentration of V+5 needed for 50% inhibition of Na+, K+-ATPase was 1.1 X 10(-6)M, 2 X 10(-7)M and 4.4 X 10(-7)M for 7-, 12- and 18-day-old rats, respectively. It is suggested that the different sensitivity of Na+, K+-ATPase towards vanadate inhibition during postnatal development might be due to age-dependent changes in the ratio of various cell types.

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Year: 1987 PMID： 3037407 DOI： 10.1007/BF01000238

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

22 in total

1. Vanadate--a new tool for biologists.

Authors: T J Simons
Journal: Nature Date: 1979-10-04 Impact factor: 49.962

2. Vanadate inhibits (Na+ + K+)ATPase by blocking a conformational change of the unphosphorylated form.

Authors: S J Karlish; L A Beaugé; I M Glynn
Journal: Nature Date: 1979-11-15 Impact factor: 49.962

3. Development of (Na+-K+)-ATPase in rat cerebrum: correlation with Na+-dependent phosphorylation and K+-paranitrophenylphosphatase.

Authors: J M Bertoni; G J Siegel
Journal: J Neurochem Date: 1978-12 Impact factor: 5.372

4. The influence of tissue treatment on brain Na+, K+-ATPase activity and its response to vanadate inhibition.

Authors: J Folbergrová
Journal: Physiol Bohemoslov Date: 1985

5. Na+-K+-activated ATPase in rat brain development.

Authors: F E Samson; D J Quinn
Journal: J Neurochem Date: 1967-04 Impact factor: 5.372

6. Postnatal formation of non-neuronal cells in the rat occipital cerebrum: an autoradiographic study of the time and space pattern of cell division.

Authors: V Mares; G Bruckner
Journal: J Comp Neurol Date: 1978-02-01 Impact factor: 3.215

7. In vivo electrical stimulation alters sensitivity of the brain (Na+ + K+)ATPase toward inhibition by vanadate.

Authors: J Krivánek
Journal: J Neurobiol Date: 1981-07

8. Development and regional distribution of two molecular forms of the catalytic subunit of the Na,K-ATPase in rat brain.

Authors: S C Specht
Journal: Biochem Biophys Res Commun Date: 1984-05-31 Impact factor: 3.575

9. Vanadyl (VO2+) and vanadate (VO-3) ions inhibit the brain microsomal Na,K-ATPase with similar affinities. Protection by transferrin and noradrenaline.

Authors: P Svoboda; J Teisinger; J Pilăr; F Vyskocil
Journal: Biochem Pharmacol Date: 1984-08-01 Impact factor: 5.858