Literature DB >> 3037383

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors.

G Grenningloh, A Rienitz, B Schmitt, C Methfessel, M Zensen, K Beyreuther, E D Gundelfinger, H Betz.   

Abstract

We have cloned and sequenced cDNAs of the strychnine-binding subunit of the rat glycine receptor, a neurotransmitter-gated chloride channel protein of the CNS. The deduced polypeptide shows significant structural and amino-acid sequence homology with nicotinic acetylcholine receptor proteins, indicating that there is a family of genes encoding neurotransmitter-gated ion channels.

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Year:  1987        PMID： 3037383     DOI： 10.1038/328215a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  137 in total

1.  The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations.

Authors:  M D Krasowski; N L Harrison
Journal:  Br J Pharmacol       Date:  2000-02       Impact factor: 8.739

2.  The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors.

Authors:  M J Gunthorpe; J A Peters; C H Gill; J J Lambert; S C Lummis
Journal:  J Physiol       Date:  2000-01-15       Impact factor: 5.182

3.  Single channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channels.

Authors:  Andrew J Moorhouse; Angelo Keramidas; Andrey Zaykin; Peter R Schofield; Peter H Barry
Journal:  J Gen Physiol       Date:  2002-05       Impact factor: 4.086

4.  Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity.

Authors:  Angelo Keramidas; Andrew J Moorhouse; Kerrie D Pierce; Peter R Schofield; Peter H Barry
Journal:  J Gen Physiol       Date:  2002-05       Impact factor: 4.086

Review 5.  The structure and function of membranes--personal memoir.

Authors:  S J Singer
Journal:  J Membr Biol       Date:  1992-07       Impact factor: 1.843

6.  Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation.

Authors:  Timothy Lynagh; Alexander Kunz; Bodo Laube
Journal:  ACS Chem Neurosci       Date:  2013-09-17       Impact factor: 4.418

7.  Introduction to thematic minireview series on celebrating the discovery of the cysteine loop ligand-gated ion channel superfamily.

Authors:  F Anne Stephenson
Journal:  J Biol Chem       Date:  2012-10-04       Impact factor: 5.157

8.  Strychnine decreases the voltage-dependent Ca2+ current of both Aplysia and frog ganglion neurons.

Authors:  Y Oyama; N Akaike; D O Carpenter
Journal:  Cell Mol Neurobiol       Date:  1988-09       Impact factor: 5.046

9.  Strychnine affects catecholamine secretion from bovine adrenal medulla chromaffin cells.

Authors:  D E Dar; O Zinder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-07       Impact factor: 3.000

10.  Charge selectivity of the designed uncharged peptide ion channel Ac-(LSSLLSL)3-CONH2.

Authors:  P K Kienker; J D Lear
Journal:  Biophys J       Date:  1995-04       Impact factor: 4.033
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