Literature DB >> 3037340

Microinjection of ras p21 induces a rapid rise in intracellular pH.

N Hagag, J C Lacal, M Graber, S Aaronson, M V Viola.   

Abstract

Quiescent mouse NIH 3T3 cells responded to microinjection of activated ras p21 with a rapid and sustained rise in intracellular pH (approximately 0.17 pH units). The p21-induced pH change was inhibited by amiloride treatment or growth of cells in medium low in sodium, suggesting a role for the Na+/H+ antiporter. Amiloride was found to suppress p21-induced mitosis, also.

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Year:  1987        PMID： 3037340      PMCID： PMC365306          DOI： 10.1128/mcb.7.5.1984-1988.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  38 in total

1.  Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production.

Authors:  M J Wakelam; S A Davies; M D Houslay; I McKay; C J Marshall; A Hall
Journal:  Nature       Date:  1986 Sep 11-17       Impact factor: 49.962

2.  Phorbol ester stimulation of Na influx and Na-K pump activity in Swiss 3T3 cells.

Authors:  P Dicker; E Rozengurt
Journal:  Biochem Biophys Res Commun       Date:  1981-05-15       Impact factor: 3.575

3.  Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.

Authors:  J Pouysségur; J C Chambard; A Franchi; S Paris; E Van Obberghen-Schilling
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

4.  A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.

Authors:  E P Reddy; R K Reynolds; E Santos; M Barbacid
Journal:  Nature       Date:  1982-11-11       Impact factor: 49.962

5.  Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series.

Authors:  G L'Allemain; A Franchi; E Cragoe; J Pouysségur
Journal:  J Biol Chem       Date:  1984-04-10       Impact factor: 5.157

6.  Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts.

Authors:  W H Moolenaar; R Y Tsien; P T van der Saag; S W de Laat
Journal:  Nature       Date:  1983 Aug 18-24       Impact factor: 49.962

7.  Activation of Na+/H+ exchange by epidermal growth factor elevates intracellular pH in A431 cells.

Authors:  P Rothenberg; L Glaser; P Schlesinger; D Cassel
Journal:  J Biol Chem       Date:  1983-10-25       Impact factor: 5.157

8.  Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization.

Authors:  S Schuldiner; E Rozengurt
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

Review 9.  Amiloride: a molecular probe of sodium transport in tissues and cells.

Authors:  D J Benos
Journal:  Am J Physiol       Date:  1982-03

10.  Cytoplasmic pH and free Mg2+ in lymphocytes.

Authors:  T J Rink; R Y Tsien; T Pozzan
Journal:  J Cell Biol       Date:  1982-10       Impact factor: 10.539
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  23 in total

1.  Early regulation of membrane excitability by ras oncogene proteins.

Authors:  C Collin; A G Papageorge; M Sakakibara; P L Huddie; D R Lowy; D L Alkon
Journal:  Biophys J       Date:  1990-09       Impact factor: 4.033

2.  Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.

Authors:  Nelson B Cole; Diane Dieuliis; Paul Leo; Drake C Mitchell; Robert L Nussbaum
Journal:  Exp Cell Res       Date:  2008-03-28       Impact factor: 3.905

3.  Rapid activation of sodium-proton exchange and extracellular signal-regulated protein kinase in fibroblasts by G protein-coupled 5-HT1A receptor involves distinct signalling cascades.

Authors:  M N Garnovskaya; Y Mukhin; J R Raymond
Journal:  Biochem J       Date:  1998-02-15       Impact factor: 3.857

Review 4.  Role of intracellular pH in proliferation, transformation, and apoptosis.

Authors:  L D Shrode; H Tapper; S Grinstein
Journal:  J Bioenerg Biomembr       Date:  1997-08       Impact factor: 2.945

5.  A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.

Authors:  X Lin; D L Barber
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

Review 6.  Control of myogenic differentiation by cellular oncogenes.

Authors:  M D Schneider; E N Olson
Journal:  Mol Neurobiol       Date:  1988       Impact factor: 5.590

Review 7.  Role of pHi, and proton transporters in oncogene-driven neoplastic transformation.

Authors:  Stephan Joel Reshkin; Maria Raffaella Greco; Rosa Angela Cardone
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2014-02-03       Impact factor: 6.237

8.  Leader length and secondary structure modulate mRNA function under conditions of stress.

Authors:  M Kozak
Journal:  Mol Cell Biol       Date:  1988-07       Impact factor: 4.272

9.  Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

Authors:  L A Feig; G M Cooper
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

10.  Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase.

Authors:  R A Gottlieb; H A Giesing; J Y Zhu; R L Engler; B M Babior
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205
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