Literature DB >> 3037312

Adeno-associated virus gene expression inhibits cellular transformation by heterologous genes.

M A Labow, L H Graf, K I Berns.   

Abstract

In this paper we report that adeno-associated virus (AAV) genomes inhibit stable transformation by several dominant selectable marker genes upon cotransfection into mouse tissue culture cells. Cotransfection of AAV genomes also inhibited the expression of pSV2cat in transient assays. In both cases, the inhibitory effect was independent of AAV DNA replication but required the AAV p5 and p19 genes, which encode proteins required for AAV DNA replication and regulation of AAV gene expression. Finally, addition of a cloned E4 gene in the transfection experiments partially blocked the AAV-mediated inhibitory activities.

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Year:  1987        PMID： 3037312      PMCID： PMC365216          DOI： 10.1128/mcb.7.4.1320-1325.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  41 in total

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Journal:  Virology       Date:  1967-11       Impact factor: 3.616

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Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272
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  62 in total

1.  Factors affecting the terminal resolution site endonuclease, helicase, and ATPase activities of adeno-associated virus type 2 Rep proteins.

Authors:  J Wu; M D Davis; R A Owens
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

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Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

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Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

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Authors:  K I Berns
Journal:  Microbiol Rev       Date:  1990-09

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Authors:  S L Rhode
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

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Authors:  J P Trempe; B J Carter
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

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Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

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Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

9.  Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein.

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Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

10.  Characterization of cell lines that inducibly express the adeno-associated virus Rep proteins.

Authors:  Q Yang; F Chen; J P Trempe
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103
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