Hossein Derakhshankhah1, Samira Jafari2. 1. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of medical Sciences, Kermanshah, Iran. 2. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of medical Sciences, Kermanshah, Iran. Electronic address: samiraa.jafari1362@gmail.com.
Abstract
INTRODUCTION: The biological membranes as natural permeable barriers are required for survival and function of living cells. However, these natural barriers could be a major obstacle for the efficient intracellular delivery of therapeutic agents. MATERIALS AND METHODS: In recent two decades, the use of peptides as novel carriers for intracellular cargo delivery has been received more attention by introducing the cell penetrating peptides (CPPs). CPPs, protein transduction domains, are an attractive class of short peptide sequences which can translocate across the cell membrane. CONCLUSION: Owing to the ability of CPPs to transport across cellular membrane, they can employ as an appropriate carrier for various cargos include nucleic acid, proteins, SiRNA, therapeutic agents, nanoparticles and so on. In this review, we describe the classifications of CPPs, their uptake mechanisms as well as biomedical applications of the CPPs.
INTRODUCTION: The biological membranes as natural permeable barriers are required for survival and function of living cells. However, these natural barriers could be a major obstacle for the efficient intracellular delivery of therapeutic agents. MATERIALS AND METHODS: In recent two decades, the use of peptides as novel carriers for intracellular cargo delivery has been received more attention by introducing the cell penetrating peptides (CPPs). CPPs, protein transduction domains, are an attractive class of short peptide sequences which can translocate across the cell membrane. CONCLUSION: Owing to the ability of CPPs to transport across cellular membrane, they can employ as an appropriate carrier for various cargos include nucleic acid, proteins, SiRNA, therapeutic agents, nanoparticles and so on. In this review, we describe the classifications of CPPs, their uptake mechanisms as well as biomedical applications of the CPPs.
Authors: Claudia C Bippes; Corina Kohler; Esther Garcia-Tirado; Reto Burri; Tina Frauenknecht; Marie-Apolline Gerard; Marie Salat; Roy Allenspach; Cavit Agca; Zongsong Wu; Andrea Trost; Barbara Bogner; Peter Meyer; Hendrik P N Scholl; Herbert Reitsamer; Josef Flammer; Albert Neutzner Journal: Mol Ther Date: 2021-09-20 Impact factor: 11.454
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