Molluscum contagiosum virus infection can trigger atopic dermatitis disease onset or flare.

Predisposition to cutaneous viral infections is known to be a minor criterion of Hanifin and Rajka's diagnostic standard of atopic dermatitis (AD); however, the causal relationship between molluscum contagiosum virus (MCV) infection and AD onset or aggravation has not been widely explored. The objective of this study was to identify pediatric patients with AD onset or flare triggered by MCV infection as well as to characterize the setting under which MCV may trigger AD onset or flares in children. Fifty children with prior or current MCV infection presenting sequentially to an outpatient pediatric dermatology practice over a 1-month period were evaluated. Results indicated that children who contract MCV infection may be targets for skin care interventions to prevent and/or control AD.