Literature DB >> 3037019

Immune response to rotavirus polypeptides after vaccination with heterologous rotavirus vaccines (RIT 4237, RRV-1).

L Svensson, H Sheshberadaran, T Vesikari, E Norrby, G Wadell.   

Abstract

The antibody response to individual rotavirus polypeptides after vaccination with live attenuated heterologous rotavirus vaccines was studied with a radioimmunoprecipitation assay (RIPA). Following vaccination with bovine rotavirus strain RIT 4237 and rhesus monkey rotavirus strain RRV-1, an antibody response was demonstrated mainly against the inner capsid polypeptides VP2 and VP6 and to a lesser extent against VP3/VP4. There was no qualitative difference between the vaccines in the antibody response; both vaccines induced antibodies against the same polypeptides. Quantitatively the antibody response to RRV-1 was somewhat stronger. All prevaccination sera contained by RIPA low levels of rotavirus antibodies. The effect of these antibodies on the 'take' of the vaccines is discussed.

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Year:  1987        PMID： 3037019     DOI： 10.1099/0022-1317-68-7-1993

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  17 in total

1.  Serum-neutralizing antibody to VP4 and VP7 proteins in infants following vaccination with WC3 bovine rotavirus.

Authors:  R L Ward; D R Knowlton; H B Greenberg; G M Schiff; D I Bernstein
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

2.  Antibody-secreting cell responses to rotavirus proteins in gnotobiotic pigs inoculated with attenuated or virulent human rotavirus.

Authors:  K O Chang; O H Vandal; L Yuan; D C Hodgins; L J Saif
Journal:  J Clin Microbiol       Date:  2001-08       Impact factor: 5.948

3.  Quantification of systemic and local immune responses to individual rotavirus proteins during rotavirus infection in mice.

Authors:  S Ishida; N Feng; B Tang; J M Gilbert; H B Greenberg
Journal:  J Clin Microbiol       Date:  1996-07       Impact factor: 5.948

4.  Relative concentrations of serum neutralizing antibody to VP3 and VP7 proteins in adults infected with a human rotavirus.

Authors:  R L Ward; D R Knowlton; G M Schiff; Y Hoshino; H B Greenberg
Journal:  J Virol       Date:  1988-05       Impact factor: 5.103

5.  Homotypic serum antibody responses to rotavirus proteins following primary infection of young children with serotype 1 rotavirus.

Authors:  S C Richardson; R F Bishop
Journal:  J Clin Microbiol       Date:  1990-09       Impact factor: 5.948

6.  Polypeptide specificity of antiviral serum antibodies in children naturally infected with human rotavirus.

Authors:  H Brüssow; P A Offit; G Gerna; A Bruttin; J Sidoti
Journal:  J Virol       Date:  1990-09       Impact factor: 5.103

7.  VP4-specific intestinal antibody response to rotavirus in a murine model of heterotypic infection.

Authors:  R D Shaw; W S Groene; E R Mackow; A A Merchant; E H Cheng
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

Review 8.  Rotavirus vaccines: an overview.

Authors:  Penelope H Dennehy
Journal:  Clin Microbiol Rev       Date:  2008-01       Impact factor: 26.132

9.  Serum IgA immune response to individual rotavirus polypeptides in young children with rotavirus infection.

Authors:  K Johansen; L Granqvist; K Karlén; G Stintzing; I Uhnoo; L Svensson
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

10.  Immunization with baculovirus-expressed recombinant rotavirus proteins VP1, VP4, VP6, and VP7 induces CD8+ T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice.

Authors:  T Dharakul; M Labbe; J Cohen; A R Bellamy; J E Street; E R Mackow; L Fiore; L Rott; H B Greenberg
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103
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