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Literature DB >> 3036997

A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types.

C Transy, S R Nash, B David-Watine, M Cochet, S W Hunt, L E Hood, P Kourilsky.

Abstract

We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.

Entities: Gene Species

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Year: 1987 PMID： 3036997 PMCID： PMC2189607 DOI： 10.1084/jem.166.2.341

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

46 in total

1. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse.

Authors: E H Weiss; L Golden; K Fahrner; A L Mellor; J J Devlin; H Bullman; H Tiddens; H Bud; R A Flavell
Journal: Nature Date: 1984 Aug 23-29 Impact factor: 49.962

2. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors: D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal: Nucleic Acids Res Date: 1984-09-25 Impact factor: 16.971

Review 3. Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.

Authors: H R MacDonald; A L Glasebrook; C Bron; A Kelso; J C Cerottini
Journal: Immunol Rev Date: 1982 Impact factor: 12.988

4. Absence of significant H-2 and beta 2-microglobulin mRNA expression by mouse embryonal carcinoma cells.

Authors: D Morello; F Daniel; P Baldacci; Y Cayre; G Gachelin; P Kourilsky
Journal: Nature Date: 1982-03-18 Impact factor: 49.962

5. Epstein Barr virus selective T cells in infectious mononucleosis are not restricted to HLA-A and B antigens.

Authors: J Seeley; E Svedmyr; O Weiland; G Klein; E Moller; E Eriksson; K Andersson; L van der Waal
Journal: J Immunol Date: 1981-07 Impact factor: 5.422

6. Clusters of genes encoding mouse transplantation antigens.

Authors: M Steinmetz; A Winoto; K Minard; L Hood
Journal: Cell Date: 1982-03 Impact factor: 41.582

7. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

8. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

Authors: S C Meuer; S F Schlossman; E L Reinherz
Journal: Proc Natl Acad Sci U S A Date: 1982-07 Impact factor: 11.205

9. Recognition of chemical carcinogen-modified DNA by a DNA-binding protein.

Authors: F Moranelli; M W Lieberman
Journal: Proc Natl Acad Sci U S A Date: 1980-06 Impact factor: 11.205

10. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.

Authors: M Steinmetz; K W Moore; J G Frelinger; B T Sher; F W Shen; E A Boyse; L Hood
Journal: Cell Date: 1981-09 Impact factor: 41.582

32 in total

A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types.

1. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse.

2. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Review 3. Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.

4. Absence of significant H-2 and beta 2-microglobulin mRNA expression by mouse embryonal carcinoma cells.

5. Epstein Barr virus selective T cells in infectious mononucleosis are not restricted to HLA-A and B antigens.

6. Clusters of genes encoding mouse transplantation antigens.

7. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

8. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

9. Recognition of chemical carcinogen-modified DNA by a DNA-binding protein.

10. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.

1. Expression of the thymus leukemia antigen in mouse intestinal epithelium.

Review 2. Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.

3. Nucleotide sequence of the BALB/c H-2T region gene, T3d.

Review 4. Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity.

5. Revised nomenclature of mouse H-2 genes.

6. Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide.

Review 7. Qa-1 restriction of CD8+ suppressor T cells.

8. HLA class I homologous transcripts in the human embryonal carcinoma cell line Tera-2.

9. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.

10. Constitutive and regulated expression of the class IB molecule Qa-1 in pancreatic beta cells.