Literature DB >> 303685

B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production.

M K Hoffmann, C Galanos, S Koenig, H F Oettgen.   

Abstract

The role played by macrophages in two effects of lipopolysaccharide (LPS) on the immune system of the mouse-substitution for helper T cells and induction of B-cell mitosis-has been investigated. C3H/HeJ mice are unresponsive and do not produce (as other strains do) antibody to 2,4,6-trinitrophenol (TNP) conjugated with autologous mouse erythrocytes (MRBC-TNP) in the presence of LPS. We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a) LPS and macrophages from LPS-responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([TNS] induced by LPS in responsive mice) are added. The mitotic response was not restored. The findings suggest that adjuvanticity and mitogenicity represent distinct pathways of B-cell activation by LPS, subject to different regulatory mechanisms.

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Year:  1977        PMID： 303685      PMCID： PMC2181908          DOI： 10.1084/jem.146.6.1640

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  22 in total

1.  Induction of phenotypic lymphocyte differentiation in LPS unresponsive mice by an LPS-induced serum factor and by lipid A-associated protein.

Authors:  S Koenig; M K Hoffmann; L Thomas
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422

2.  Endotoxin-induced serum factor controlling differentiation of bone-marrow-derived lymphocytes.

Authors:  M K Hoffmann; H F Oettgen; L J Old; A F Chin; U Hammerling
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

3.  Enhancement of the humoral response of T cell-depleted murine spleens by a factor derived from human monocytes in vitro.

Authors:  D D Wood; S L Gaul
Journal:  J Immunol       Date:  1974-09       Impact factor: 5.422

4.  Separation of mouse spleen cells by passage through columns of sephadex G-10.

Authors:  I A Ly; R I Mishell
Journal:  J Immunol Methods       Date:  1974-08       Impact factor: 2.303

5.  PPD tuberculin--a B-cell mitogen.

Authors:  B M Sultzer; B S Nilsson
Journal:  Nat New Biol       Date:  1972-12-13

6.  Serum containing endotoxin-induced tumour necrosis factor substitutes for helper T cells.

Authors:  M K Hoffmann; S Green; L J Old; H F Oettgen
Journal:  Nature       Date:  1976-09-30       Impact factor: 49.962

7.  Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities.

Authors:  B J Skidmore; J M Chiller; D C Morrison; W O Weigle
Journal:  J Immunol       Date:  1975-02       Impact factor: 5.422

8.  Partial purification of a serum factor that causes necrosis of tumors.

Authors:  S Green; A Dobrjansky; E A Carswell; R L Kassel; L J Old; N Fiore; M K Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

9.  Mechanism of activation of the bone marrow-derived lymphocyte. 3. A distinction between a macrophage-produced triggering signal and the amplifying effect on triggered B lymphocytes of allogeneic interactions.

Authors:  J W Schrader
Journal:  J Exp Med       Date:  1973-12-01       Impact factor: 14.307

10.  Isolation of a lipid A bound polypeptide responsible for "LPS-initiated" mitogenesis of C3H/HeJ spleen cells.

Authors:  D C Morrison; S J Betz; D M Jacobs
Journal:  J Exp Med       Date:  1976-09-01       Impact factor: 14.307
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  15 in total

1.  Down-regulation of immune responses to inhaled antigen: studies on the mechanism of induced suppression.

Authors:  J D Sedgwick; P G Holt
Journal:  Immunology       Date:  1985-12       Impact factor: 7.397

2.  Immunodepression in Taenia crassiceps infection: restoration of the in vitro response to sheep erythrocytes by activated peritoneal cells.

Authors:  K L Miller; A H Good; R I Mishell
Journal:  Infect Immun       Date:  1978-11       Impact factor: 3.441

3.  Nrf2-dependent and -independent effects of tBHQ in activated murine B cells.

Authors:  Jenna K Bursley; Cheryl E Rockwell
Journal:  Food Chem Toxicol       Date:  2020-07-20       Impact factor: 6.023

4.  Relationships between adjuvant, immunosuppressive, and mitogenic activities of staphylococcal peptidoglycan.

Authors:  R Dziarski
Journal:  Infect Immun       Date:  1979-11       Impact factor: 3.441

Review 5.  The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.

Authors:  Isabel Wong-Baeza; Marcela Alcántara-Hernández; Ismael Mancilla-Herrera; Itzmel Ramírez-Saldívar; Lourdes Arriaga-Pizano; Eduardo Ferat-Osorio; Constantino López-Macías; Armando Isibasi
Journal:  J Biomed Biotechnol       Date:  2010-01-21

6.  In vivo immune response to a T-cell-dependent antigen by cultures of disassociated murine Peyer's patch.

Authors:  H Kiyono; J R McGhee; M J Wannemuehler; M V Frangakis; D M Spalding; S M Michalek; W J Koopman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

7.  Activation of human T and non-T lymphocytes by sepharose-bound concanavalin A and the differential effect of macrophages.

Authors:  S Terukina; S Arai
Journal:  Immunology       Date:  1981-10       Impact factor: 7.397

8.  In vitro stimulation of immunoglobulin production from human peripheral blood lymphocytes by a soluble preparation of Actinomyces viscosus.

Authors:  D F Mangan; D E Lopatin
Journal:  Infect Immun       Date:  1981-01       Impact factor: 3.441

9.  Bacterial lipopolysaccharide activates suppressor B lymphocytes.

Authors:  S Koenig; M K Hoffmann
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

10.  CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses.

Authors:  Yo-Ping Lai; Chia-Ching Lin; Wan-Jung Liao; Chih-Yung Tang; Shu-Ching Chen
Journal:  PLoS One       Date:  2009-11-10       Impact factor: 3.240
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